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芬格鲁胺

芬格鲁胺用途

Phenglutarimid 是一种抗胆碱能药,用作抗帕金森病药。

芬格鲁胺名称

[ CAS 号 ]:
1156-05-4

[ 中文名 ]:
芬格鲁胺

[ 英文名 ]:
Phenglutarimid

[英文别名 ]:

ATURBANE
Aturban
2-(2-(Diethylamino)ethyl)-2-phenylglutarimide
Einecs 214-587-8
GLUTARIMIDE,2-((2-DIETHYLAMINO)ETHYL)-2-PHENYL
Phenglutarimid

芬格鲁胺生物活性

[ 描述 ]:

Phenglutarimid 是一种抗胆碱能药,用作抗帕金森病药。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 神经疾病

[ 靶点 ]

anticholinergic[1]

[参考文献]

[1]. BATTEGAY R. [Aturban (phenglutarimide), a new therapeutic drug for parkinsonism; comparative investigation on the therapy of parkinsonism].

芬格鲁胺物理化学性质

[ 密度 ]:
1.072g/cm3

[ 沸点 ]:
447.8ºC at 760mmHg

[ 分子式 ]:
C₁₇H₂₄N₂O₂

[ 分子量 ]:
288.38500

[ 闪点 ]:
224.6ºC

[ 精确质量 ]:
288.18400

[ PSA ]:
49.41000

[ LogP ]:
2.42170

芬格鲁胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA4130000

CHEMICAL NAME :: Glutarimide, 2-(2-(diethylamino)ethyl)-2-phenyl-

CAS REGISTRY NUMBER :: 1156-05-4

BEILSTEIN REFERENCE NO. :: 0270870

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H24-N2-O2

MOLECULAR WEIGHT :: 288.43

WISWESSER LINE NOTATION :: T6VMVTJ D2N2&2 DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,255,1961

芬格鲁胺安全信息

[ 海关编码 ]:
2925190090

芬格鲁胺海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%