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甘丙肽

甘丙肽用途

Galanin (1-30), human 是由 30 个氨基酸构成的神经肽，为甘丙肽 GalR1 和 GalR2 受体的有效激动剂，K_i 值均为 1 nM。

甘丙肽名称

[ CAS 号 ]:
119418-04-1

[ 中文名 ]:
甘丙肽

[ 英文名 ]:
Galanin (human) acetate salt

[英文别名 ]:

MFCD00135986
Galanin,Human
Galanin-1-30
Galanin (1-30), human

甘丙肽生物活性

[ 描述 ]:

Galanin (1-30), human 是由 30 个氨基酸构成的神经肽,为甘丙肽 GalR1 和 GalR2 受体的有效激动剂,Ki 值均为 1 nM。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体

多肽产品

研究领域 >> 神经疾病

[ 靶点 ]

Kd: 1 nM (GalR1 receptor), 1 nM (GalR2 receptor)[2]

[体外研究]

甘丙肽(1-30),人(Gal1-30)是GalR1和GalR2受体的激动剂,Kis均为1 nM [1]。甘丙肽(1-30),人取代125I标记的大鼠甘丙肽,Kd为0.5nM。甘丙肽(1-30),人(hGal)引起孤立的纵向大鼠眼底条的收缩,ED50为13.8±1.6 nM [2]。

[参考文献]

[1]. Hua XY, et al. Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther. 2004 Feb;308(2):574-82.

[2]. Schmidt WE, et al. Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11435-9.

[相关活性小分子]

甘丙肽物理化学性质

[ 分子式 ]:
C₁₃₉H₂₁₀N₄₂O₄₃

[ 分子量 ]:
3157.41000

[ 精确质量 ]:
3155.55000

[ PSA ]:
1367.68000

[ 外观性状 ]:
粉末

甘丙肽安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

甘丙肽文献

The Influence of Low Doses of Zearalenone on Distribution of Selected Active Substances in Nerve Fibers Within the Circular Muscle Layer of Porcine Ileum.

J. Mol. Neurosci. 56(4) , 878-86, (2015)

The aim of this study was to investigate, whether low doses (25 % of no observable adverse effect levels values) of zearalenone (ZEN) can affect the expression of active substances in nerve fibers in ...

Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer.

Oncol. Rep. 33(2) , 539-46, (2015)

Reliable predictors of tumor recurrence for patients with stage II colorectal cancer (CRC) are needed to select patients who should receive adjuvant chemotherapy. Although galanin (GAL) is expressed i...

Association of galanin and major depressive disorder in the Chinese Han population.

PLoS ONE 8(5) , e64617, (2013)

This study aimed to investigate the association of galanin (GAL) gene and the development of depression in the Chinese Han population.A total of 700 patients with depression who met the diagnostic cri...

更多文献

甘丙肽

甘丙肽用途

甘丙肽名称

甘丙肽生物活性

甘丙肽物理化学性质

甘丙肽安全信息

甘丙肽文献

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