<生产厂家价格>

氟虫腈砜

氟虫腈砜用途

Fipronil sulfone 是氟虫腈的主要代谢物。氟虫腈砜选择性抑制 GABA受体,IC50 值为 175 nM(通过从非竞争性阻滞剂位点 ([3H]EBOB)来测定)。

氟虫腈砜名称

[ CAS 号 ]:
120068-36-2

[ 中文名 ]:
氟虫腈砜

[ 英文名 ]:
FIPRONIL-SULFONE

[英文别名 ]:

Fipronil sulfone
FIPRONIL-SULFONE
T5NNJ AR BG FG DXFFF& CCN DSWXFFF EZ

氟虫腈砜生物活性

[ 描述 ]:

Fipronil sulfone 是氟虫腈的主要代谢物。氟虫腈砜选择性抑制 GABA受体,IC50 值为 175 nM(通过从非竞争性阻滞剂位点 ([3H]EBOB)来测定)。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[参考文献]

[1]. D Hainzl,et al. Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproduct. Chem Res Toxicol . 1998 Dec;11(12):1529-35.

氟虫腈砜物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
531.6±50.0 °C at 760 mmHg

[ 分子式 ]:
C₁₂H₄Cl₂F₆N₄O₂S

[ 分子量 ]:
453.147

[ 闪点 ]:
275.3±30.1 °C

[ 精确质量 ]:
451.933624

[ PSA ]:
110.15000

[ LogP ]:
7.44

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.592

[ 储存条件 ]:
室温，密闭，干燥

氟虫腈砜MSDS

氟虫腈砜安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H400

[ 警示性声明 ]:
P273-P301 + P310

[ 危害码 (欧洲) ]:
T,N

[ 风险声明 (欧洲) ]:
25-50

[ 安全声明 (欧洲) ]:
45-61

[ 危险品运输编码 ]:
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all

[ RTECS号 ]:
UQ3515375

氟虫腈砜合成路线

氟虫腈砜上下游产品

氟虫腈砜上游产品

氟虫腈砜下游产品

氟虫腈砜文献

Persistence and effect of processing on reduction of fipronil and its metabolites in chilli pepper (Capsicum annum L.) fruits.

Environ. Monit. Assess. 186(9) , 5429-37, (2014)

A single laboratory UPLC-MS/MS method was developed and validated for the estimation of fipronil and its metabolites in fresh and dry chilli pepper fruits. Dissipation of fipronil on chilli fruits was...

Fipronil sulfone induced higher cytotoxicity than fipronil in SH-SY5Y cells: Protection by antioxidants.

Toxicol. Lett. 252 , 42-9, (2016)

Fipronil is a broad spectrum insecticide from the phenyl pyrazole family, which targets GABA receptor. Limited information is available about the metabolite fipronil sulfone cytotoxic actions. This st...

DBS-platform for biomonitoring and toxicokinetics of toxicants: proof of concept using LC-MS/MS analysis of fipronil and its metabolites in blood.

Sci. Rep. 6 , 22447, (2016)

A simple, sensitive and high throughput LC-MS/MS method was developed and validated for quantification of fipronil, fipronil sulfone and fipronil desulfinyl in rat and human dried blood spots (DBS). D...

更多文献