佐利米定

佐利米定用途

唑咪啶是咪唑并吡啶的衍生物,是一种口服活性抗溃疡剂。唑胺刺激肠粘膜细胞分泌粘液,增强肠壁对溃疡的抵抗力。唑胺在十二指肠溃疡研究中显示出胃保护作用[1][2]。

佐利米定名称

[ CAS 号 ]:
1222-57-7

[ 中文名 ]:
佐利米定

[ 英文名 ]:
2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine

[中文别名 ]:

[英文别名 ]:

佐利米定生物活性

[ 描述 ]:

唑咪啶是咪唑并吡啶的衍生物,是一种口服活性抗溃疡剂。唑胺刺激肠粘膜细胞分泌粘液,增强肠壁对溃疡的抵抗力。唑胺在十二指肠溃疡研究中显示出胃保护作用[1][2]。

[ 相关类别 ]:

研究领域 >> 内分泌
信号通路 >> 其他 >> 其他

[体内研究]

唑亚胺定(200 mg/kg口服) 降低由 吲哚美辛(HY-14397)(5 mg/kg/天,持续 8.天,直肠) 诱导的大鼠肠道溃疡的发生率[2] 唑亚胺定(加在饮食中；1%含量) 可降低豚鼠由角叉菜胶 (加在饮用水中；5%含量,持续 40天) 引起的肠溃疡的发生率[2]

[参考文献]

[1]. Belohlavek D, et al. The effect of zolimidine, imidazopyridine-derivate, on the duodenal ulcer healing. Scand J Gastroenterol Suppl. 1979;54:44.  

[2]. Carminati GM, et al. Protective action of zolimidine against two different types of experimental intestinal ulcers. Farmaco, Edizione Pratica (1978), 33(2), 68-79.

佐利米定物理化学性质

[ 密度 ]:
1.31 g/cm3

[ 分子式 ]:
C14H12N2O2S

[ 分子量 ]:
272.32

[ 精确质量 ]:
272.06200

[ PSA ]:
59.82000

[ LogP ]:
3.48560

[ 折射率 ]:
1.653

佐利米定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ5758500
CHEMICAL NAME :
Imidazo(1,2-a)pyridine, 2-(p-(methylsulfonyl)phenyl)-
CAS REGISTRY NUMBER :
1222-57-7
BEILSTEIN REFERENCE NO. :
0752451
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C14-H12-N2-O2-S
MOLECULAR WEIGHT :
272.34
WISWESSER LINE NOTATION :
T56 AN DNJ CR DSW1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3710 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3318880
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
950 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1655,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #8177M
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
765 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #8177M

佐利米定安全信息

[ 海关编码 ]:
2933990090

佐利米定合成路线

详细合成路线

佐利米定海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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