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硬脂酸酰胺

硬脂酸酰胺用途

硬脂酰胺是一种主要的脂肪酸酰胺。硬脂酰胺具有细胞毒性和鱼类毒性[1]。

硬脂酸酰胺名称

[ CAS 号 ]:
124-26-5

[ 中文名 ]:
硬脂酰胺

[ 英文名 ]:
Stearic acid amide

[中文别名 ]:

[英文别名 ]:

Octadecamide
stearic amide
Octadecanamide
stearylamide
distearyl amide
Octadecylamide
STEARIC ACID AMIDE
EINECS 204-693-2
Stearoylamide
stearoylamine

硬脂酸酰胺生物活性

[ 描述 ]:

硬脂酰胺是一种主要的脂肪酸酰胺。硬脂酰胺具有细胞毒性和鱼类毒性[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Matthew J.Bertin, et al. Identification of toxic fatty acid amides isolated from the harmful alga Prymnesium parvum carter.

硬脂酸酰胺物理化学性质

[ 密度 ]:
0.868 g/cm3

[ 沸点 ]:
250-251 °C12 mm Hg(lit.)

[ 熔点 ]:
98-102 °C(lit.)

[ 分子式 ]:
C₁₈H₃₇NO

[ 分子量 ]:
283.49200

[ 闪点 ]:
207.5ºC

[ 精确质量 ]:
283.28800

[ PSA ]:
43.09000

[ LogP ]:
6.43350

[ 外观性状 ]:
淡黄色颗粒

[ 蒸汽压 ]:
7.11E-07mmHg at 25°C

[ 折射率 ]:
1.432-1.434

[ 储存条件 ]:
室温，干燥

硬脂酸酰胺MSDS

硬脂酸酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG0182000

CHEMICAL NAME :: Octadecanamide

CAS REGISTRY NUMBER :: 124-26-5

BEILSTEIN REFERENCE NO. :: 0909006

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H37-N-O

MOLECULAR WEIGHT :: 283.56

WISWESSER LINE NOTATION :: ZV17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 26,105,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M4134 No. of Facilities: 119 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 1994 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M4134 No. of Facilities: 529 (estimated) No. of Industries: 11 No. of Occupations: 20 No. of Employees: 23611 (estimated) No. of Female Employees: 11289 (estimated)

硬脂酸酰胺安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
RG0182000

[ 海关编码 ]:
2924199090

硬脂酸酰胺合成路线

硬脂酸酰胺上下游产品

硬脂酸酰胺上游产品

硬脂酸酰胺下游产品

硬脂酸酰胺制备

1.将1 mol硬脂酸投入反应釜加热熔融。在搅拌下继续升温至200 ℃，开始通入氨气。氨气从釜底通入，加快搅拌速度，加强气态与液态的接触。副产物水和未反应的氨气通过冷凝系统进入回收装置。当通入氨气相当硬脂酸质量份数的2倍时，取气样检验，如果气体中不再含有水，反应到终点。停止通氨，趁热出料加工成型。用乙醇溶解后加入活性炭脱色，趁热过滤，冷却结晶，水洗晶体，干燥即为纯品。

硬脂酸酰胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

硬脂酸酰胺文献

Development and validation of method for TH588 and TH287, potent MTH1 inhibitors and new anti-cancer agents, for pharmacokinetic studies in mice plasma.

J. Pharm. Biomed. Anal. 104 , 1-11, (2014)

MTH1 is a protein that is required for cancer cell survival and is overexpressed in cancer cells. TH588 and TH287 are two new compounds that inhibit the MTH1 protein. The inhibitors were tested in pha...

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