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十八烷基二甲基叔胺

十八烷基二甲基叔胺用途

强力霉素是一种驱虫药。强力霉素有可能研究多种肠道蠕虫感染[1][2]。

十八烷基二甲基叔胺名称

[ CAS 号 ]:
124-28-7

[ 中文名 ]:
十八烷基二甲基叔胺

[ 英文名 ]:
Dymanthine

[中文别名 ]:

[英文别名 ]:

EINECS 204-694-8
GS-1339
Onamine 18
dimethyloctadecylamine
Amine 2M18D
dimethyl stearyl amine
N-octadecyldimethylamine
Dimanthine
Thelmesan
Adma 18

十八烷基二甲基叔胺生物活性

[ 描述 ]:

强力霉素是一种驱虫药。强力霉素有可能研究多种肠道蠕虫感染[1][2]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Chari MV, et al. Dymanthine hydrochloride (thelmasan) in multiple intestinal helmintic infestations. J Assoc Physicians India. 1967;15(3):143-145.

[2]. De Leon GV, et al. Basic studies on the anthelminthic action of dymanthine (Thelmesan). Acta Med Philipp. 1965;2(1):10-15.

十八烷基二甲基叔胺物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
348.5±5.0 °C at 760 mmHg

[ 熔点 ]:
23 °C

[ 分子式 ]:
C₂₀H₄₃N

[ 分子量 ]:
297.562

[ 闪点 ]:
153.8±5.2 °C

[ 精确质量 ]:
297.339539

[ PSA ]:
3.24000

[ LogP ]:
9.10

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.450

[ 储存条件 ]:
室温，密封

[ 水溶解性 ]:
Slightly soluble

十八烷基二甲基叔胺MSDS

十八烷基二甲基叔胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RG4200000

CHEMICAL NAME :: Octadecylamine, N,N-dimethyl

CAS REGISTRY NUMBER :: 124-28-7

BEILSTEIN REFERENCE NO. :: 1763346

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C20-H43-N

MOLECULAR WEIGHT :: 297.64

WISWESSER LINE NOTATION :: 18N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,440,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,440,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,11,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 26,517,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4163 No. of Facilities: 64 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 1624 (estimated) No. of Female Employees: 90 (estimated)

十八烷基二甲基叔胺安全信息

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R22;R34

[ 安全声明 (欧洲) ]:
S45-S36/37/39-S26

[ 危险品运输编码 ]:
2735

[ RTECS号 ]:
RG4200000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2921199090

十八烷基二甲基叔胺合成路线

十八烷基二甲基叔胺上下游产品

十八烷基二甲基叔胺上游产品

十八烷基二甲基叔胺下游产品

十八烷基二甲基叔胺制备

生产方法简述：由十八胺、甲醛、甲酸经缩合制得。先将十八胺加入反应器，在乙醇介质中搅拌均匀，温度控制在50-60℃加入甲酸，搅拌数分钟后，在60-65℃时加入甲醛，升温至80-83℃，回流保温2h，用液碱中和，使pH值大于10，静置分层，去水，减压蒸馏脱除乙醇后经冷却，即得N，N-二甲基十八胺。原料消耗定额：十八胺（工业品）917kg/t、乙醇（95%）417kg/t、甲酸510kg/t、甲醛（37%）546kg/t。此外，还有直接由高级醇与二甲胺合成的方法。用十八醇与二甲胺在催化剂存在下，于180-220℃液相中进行催化胺化，脱去一分子水，即得粗叔胺，经减压蒸馏即得高纯度的N，N-二甲基十八胺。每吨产品消耗十八醇971kg，二甲胺170kg。

十八烷基二甲基叔胺海关

[ 海关编码 ]: 2921199090

[ 中文概述 ]:
2921199090 其他无环单胺及其衍生物及其盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%