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邻苯二甲酸二甲酯；避蚊酯

邻苯二甲酸二甲酯；避蚊酯用途

Dimethyl phthalate,一种已知的内分泌干扰物,也是一种邻苯二甲酸酯 (PAEs),也是一种普遍存在的污染物。Dimethyl phthalate 通常用作增塑剂,赋予硬质聚氯乙烯 (PVC) 树脂以柔韧性。

邻苯二甲酸二甲酯；避蚊酯名称

[ CAS 号 ]:
131-11-3

[ 中文名 ]:
邻苯二甲酸二甲酯

[ 英文名 ]:
Dimethyl phthalate

[中文别名 ]:

[英文别名 ]:

phthalic acid dimethyl ester
Phthalic acid methyl ester
1,2-Benzenedicarboxylic acid, dimethyl ester
dimethyl 4-phthalate
Dimethyl phthalate acid ester
dimethyl 1,2-benzendicarboxylate
Benzene-1,2-dicarboxylic acid dimethyl ester
Dimethyl phthalate
EINECS 205-011-6
MFCD00008425

邻苯二甲酸二甲酯；避蚊酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Wang ZG, et al. Impacts of dimethyl phthalate on the bacterial community and functions in black soils. Front Microbiol. 2015 May 5;6:405.

邻苯二甲酸二甲酯；避蚊酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
282.7±8.0 °C at 760 mmHg

[ 熔点 ]:
2 °C(lit.)

[ 分子式 ]:
C₁₀H₁₀O₄

[ 分子量 ]:
194.184

[ 闪点 ]:
146.1±0.0 °C

[ 精确质量 ]:
194.057907

[ PSA ]:
52.60000

[ LogP ]:
1.64

[ 外观性状 ]:
透明油性液体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.515

[ 储存条件 ]:
包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases, nitrates. Sensitive to prolonged exposure to light.

[ 水溶解性 ]:
<0.1 g/100 mL at 20 ºC

邻苯二甲酸二甲酯；避蚊酯MSDS

邻苯二甲酸二甲酯；避蚊酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI1575000

CHEMICAL NAME :: Phthalic acid, dimethyl ester

CAS REGISTRY NUMBER :: 131-11-3

LAST UPDATED :: 199712

DATA ITEMS CITED :: 57

MOLECULAR FORMULA :: C10-H10-O4

MOLECULAR WEIGHT :: 194.20

WISWESSER LINE NOTATION :: 1OVR BVO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - withdrawal Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3375 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - withdrawal Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6500 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 9300 mg/m3/6.5H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4400 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >20 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2400 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >10 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 8500 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1840 ug/kg/4H/17W-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Blood - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mL/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 338 mg/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 338 mg/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1125 mg/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1500 mg/kg

SEX/DURATION :: female 3-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

MUTATION DATA

TEST SYSTEM :: Rodent - rat

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 40,454,1977 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 3,73,1973 TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 54,1,1975 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 4,3,1973 TOXICOLOGY REVIEW JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),267,1985 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,91,1971 OSHA PEL (Gen Indu):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg/m3 JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FINLAND:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993 OEL-FRANCE:TWA 5 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 5 mg/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 3 mg/m3;STEL 5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIMETHYLPHTHALATE-air:10H TWA 5 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 59210 No. of Facilities: 2879 (estimated) No. of Industries: 38 No. of Occupations: 58 No. of Employees: 50231 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 59210 No. of Facilities: 6174 (estimated) No. of Industries: 56 No. of Occupations: 66 No. of Employees: 57908 (estimated) No. of Female Employees: 16352 (estimated)

邻苯二甲酸二甲酯；避蚊酯安全信息

[ 符号 ]:

GHS02, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H301 + H311 + H331-H370

[ 警示性声明 ]:
P210-P260-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
F;T

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S24/25-S45-S36/37-S16-S7

[ 危险品运输编码 ]:
UN 3082

[ WGK德国 ]:
1

[ RTECS号 ]:
TI1575000

邻苯二甲酸二甲酯；避蚊酯合成路线

邻苯二甲酸二甲酯；避蚊酯上下游产品

邻苯二甲酸二甲酯；避蚊酯上游产品

邻苯二甲酸二甲酯；避蚊酯下游产品

邻苯二甲酸二甲酯；避蚊酯制备

1、硫酸催化合成　由苯酐与过量甲醇进行常压酯化而得。过量甲醇回流带水，将600kg苯酐、450g甲醇、1050mL的浓硫酸依次投入反应锅，加热回流24h，酯化温度为甲醇回流温度。反应结束后，回收甲醇，然后用碳酸钠中和，用水洗涤，再经蒸馏即得成品。原料消耗为：苯酐750kg/t，甲醇445kg/。酯化反应式如

2、树脂催化酯化合成　D72型阳离子交换树脂使用前先用约５倍体积的盐酸水溶液［狑（HCl）＝6%～7%］浸约24h，再用去离子水冲洗树脂至pH值与所用去离子水pH值相同，然后在80℃条件下烘干。将苯酐和甲醇［狀（苯酐）∶狀（甲醇）＝1∶3］、质量分数为4%的树脂置于装有搅拌器、温度计、冷凝器、分液漏斗的四口烧瓶中搅拌，加热至110℃，反应6h时间后取样测酸值，符合要求后，停止加入甲醇，继续加热15min，冷却后滤出液体。用狑（NaOH）＝3%～4%水溶液中和至pH值7～8，静置分层，减压蒸馏，收集相应温度下的馏分，即得产品。

3. 烟草：FC，40。

邻苯二甲酸二甲酯；避蚊酯文献

Development of dispersive liquid-liquid microextraction technique using ternary solvents mixture followed by heating for the rapid and sensitive analysis of phthalate esters and di(2-ethylhexyl) adipate.

J. Chromatogr. A. 1379 , 24-33, (2015)

In this study, for the first time, a dispersive liquid-liquid microextraction technique using a ternary solvent mixture is reported. In order to extract five phthalate esters and di(2-ethylhexyl) adip...

Phthalate occurrence in rivers and tap water from central Spain.

Sci. Total Environ. 500-501 , 139-46, (2014)

The aim of this study is to evaluate the presence and concentrations of the main phthalates in water from the Jarama and Manzanares rivers in the region of Madrid (RM, Central Spain), the most densely...

Growth of cedar-like Au nanoparticles coating on an etched stainless steel wire and its application for selective solid-phase microextraction.

Anal. Chim. Acta 876 , 55-62, (2015)

A novel cedar-like Au nanoparticles (AuNPs) coating was fabricated on an etched stainless steel (SS) wire by direct chemical deposition and used as an efficient and unbreakable solid phase microextrac...

更多文献

邻苯二甲酸二甲酯；避蚊酯

邻苯二甲酸二甲酯；避蚊酯用途

邻苯二甲酸二甲酯；避蚊酯名称

邻苯二甲酸二甲酯；避蚊酯生物活性

邻苯二甲酸二甲酯；避蚊酯物理化学性质

邻苯二甲酸二甲酯；避蚊酯MSDS

详细MSDS(安全技术说明书)

邻苯二甲酸二甲酯；避蚊酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

邻苯二甲酸二甲酯；避蚊酯安全信息

邻苯二甲酸二甲酯；避蚊酯合成路线

详细合成路线

邻苯二甲酸二甲酯；避蚊酯上下游产品

邻苯二甲酸二甲酯；避蚊酯上游产品

邻苯二甲酸二甲酯；避蚊酯下游产品

邻苯二甲酸二甲酯；避蚊酯制备

邻苯二甲酸二甲酯；避蚊酯文献

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邻苯二甲酸二甲酯； 避蚊酯

邻苯二甲酸二甲酯； 避蚊酯用途

邻苯二甲酸二甲酯； 避蚊酯名称

邻苯二甲酸二甲酯； 避蚊酯生物活性

邻苯二甲酸二甲酯； 避蚊酯物理化学性质

邻苯二甲酸二甲酯； 避蚊酯MSDS

详细MSDS(安全技术说明书)

邻苯二甲酸二甲酯； 避蚊酯毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

邻苯二甲酸二甲酯； 避蚊酯安全信息

邻苯二甲酸二甲酯； 避蚊酯合成路线

详细合成路线

邻苯二甲酸二甲酯； 避蚊酯上下游产品

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邻苯二甲酸二甲酯；避蚊酯

邻苯二甲酸二甲酯；避蚊酯用途

邻苯二甲酸二甲酯；避蚊酯名称

邻苯二甲酸二甲酯；避蚊酯生物活性

邻苯二甲酸二甲酯；避蚊酯物理化学性质

邻苯二甲酸二甲酯；避蚊酯MSDS

邻苯二甲酸二甲酯；避蚊酯毒性和生态

邻苯二甲酸二甲酯；避蚊酯安全信息

邻苯二甲酸二甲酯；避蚊酯合成路线

邻苯二甲酸二甲酯；避蚊酯上下游产品

邻苯二甲酸二甲酯；避蚊酯上游产品

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邻苯二甲酸二甲酯；避蚊酯文献