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羟钴胺

羟钴胺用途

Hydroxocobalamin (Vitamin B12a) 是一种可注射的天然维生素 B12,具有良好的不良反应特征,可作为维生素 B12 缺乏症 (包括恶性贫血) 的膳食补充剂。

羟钴胺名称

[ CAS 号 ]:
13422-51-0

[ 中文名 ]:
羟钴胺

[ 英文名 ]:
Hydroxocobalamin

[中文别名 ]:

维生素 B12b

[英文别名 ]:

Hydroxocobalamin
Vitamin B12a acetate
EINECS 236-533-2
hydroxycobalamin
ohb12
vitamin B12a
duradoce
cobalex
docevita
MFCD00082532

羟钴胺生物活性

[ 描述 ]:

Hydroxocobalamin (Vitamin B12a) 是一种可注射的天然维生素 B12,具有良好的不良反应特征,可作为维生素 B12 缺乏症 (包括恶性贫血) 的膳食补充剂。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362.

[2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655.

[3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.

羟钴胺物理化学性质

[ 熔点 ]:
200ºC (decomposes)

[ 分子式 ]:
C₆₂H₈₉CoN₁₃O₁₅P

[ 分子量 ]:
1346.36

[ 精确质量 ]:
1345.567017

[ PSA ]:
484.10000

[ LogP ]:
6.43870

[ 外观性状 ]:
暗红色晶体或结晶粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
methanol: 10 mg/mL at 20 °C, clear, dark red

羟钴胺MSDS

详细MSDS(安全技术说明书)

羟钴胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GG3820000

CHEMICAL NAME :: Cobinamide, dihydroxide, dihydrogen phosphate (ester), mono (inner salt), 3'- ester with 5,6- dimethyl-1-alpha-D-ribofuranosylbenzimidazole

CAS REGISTRY NUMBER :: 13422-51-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C62-H89-Co-N13-O15-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,867,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3794 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 3157 (estimated) No. of Female Employees: 1154 (estimated)

羟钴胺安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
GG3820000

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羟钴胺文献

Pseudo-blood leak? A hemodialysis mystery.

Clin. Nephrol. 79(4) , 323-5, (2013)

Hydroxocobalamin is a treatment for cyanide toxicity with few side effects. We report a case of a hemodialysis patient whose treatment was compromised by hydroxocobalamin interference with the blood l...

A patient with an inborn error of vitamin B12 metabolism (cblF) detected by newborn screening.

Pediatrics 132(1) , e257-61, (2013)

A neonate, who was found to have an elevated C3/C2 ratio and minimally elevated propionylcarnitine on newborn screening, was subsequently identified as having the rare cblF inborn error of vitamin B12...

Severe combined immunodeficiency resulting from mutations in MTHFD1.

Pediatrics 131(2) , e629-34, (2013)

Folate and vitamin B(12) metabolism are essential for de novo purine synthesis, and several defects in these pathways have been associated with immunodeficiency. Here we describe the occurrence of sev...

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羟钴胺