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羟胺

羟胺用途

【用途一】
在有机合成中用作还原剂。

羟胺名称

[ CAS 号 ]:
7803-49-8

[ 中文名 ]:
羟胺

[ 英文名 ]:
Hydroxylamine

[中文别名 ]:

羟胺溶液

[英文别名 ]:

MFCD00044522
Hydroxylamine
EINECS 232-259-2
hydroxyl amine
Hydroxylamine solution

羟胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
56.5±9.0 °C at 760 mmHg

[ 熔点 ]:
7°C

[ 分子式 ]:
H₃NO

[ 分子量 ]:
33.030

[ 精确质量 ]:
33.021465

[ PSA ]:
46.25000

[ LogP ]:
-0.81

[ 外观性状 ]:
白色针状或片

[ 蒸汽压 ]:
179.1±0.2 mmHg at 25°C

[ 折射率 ]:
1.395

[ 储存条件 ]:
库房通风低温干燥,与可燃物分开存放

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents, potassium dichromate, chromium trioxide, zinc, calcium, copper, sodium, ammonia, carbonyls, phosphorus halides, pyridine, hypochlorites.

羟胺MSDS

羟胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NC2975000

CHEMICAL NAME :: Hydroxylamine

CAS REGISTRY NUMBER :: 7803-49-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 49

MOLECULAR FORMULA :: H3-N-O

MOLECULAR WEIGHT :: 33.04

WISWESSER LINE NOTATION :: ZQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 59 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 175 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Leukocyte

DOSE/DURATION :: 25 mg/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 6,375,1973 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84783 No. of Facilities: 116 (estimated) No. of Industries: 3 No. of Occupations: 5 No. of Employees: 1722 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84783 No. of Facilities: 112 (estimated) No. of Industries: 5 No. of Occupations: 9 No. of Employees: 2689 (estimated) No. of Female Employees: 1481 (estimated)

羟胺安全信息

[ 符号 ]:

GHS05, GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H290-H302-H315-H317-H318-H335-H351-H373-H400

[ 警示性声明 ]:
P261-P273-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R5;R22;R37/38;R41;R43;R48/22;R50

[ 安全声明 (欧洲) ]:
S23-S26-S36/37/39-S47-S61-S22

[ 危险品运输编码 ]:
UN 3082 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
NC2975000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

羟胺合成路线

羟胺上下游产品

羟胺上游产品

羟胺下游产品

羟胺制备

1.用盐酸羟胺乙醇溶液加乙醇钠，将析出的氢氧化钠迅速滤出，滤液冷至-18℃结晶，过滤，得羟胺。将磷酸羟胺加热蒸馏（1.73kPa下操作），收集135-137℃馏分，亦可得羟胺粗品。

2.制备羟胺常有两种方法，一是将某些羟胺化合物加热分解，另一种方法是盐酸羟胺与醇钠的反应。在带有搅拌器、滴液漏斗和出气管的三颈烧瓶中装入70g(1mol)干燥的盐酸胲0.02g酚酞和100mL丁醇。搅拌10min后，从滴液漏斗滴入丁醇钠(预先用23.5g金属钠和300mL丁醇，在装有回流冷凝器的烧瓶中加热制备)并强烈搅拌。滴加速度应使指示剂不遗留颜色为准。抽吸过滤除去NaCl。用15mL丁醇洗涤一次，然后用无水乙醇洗3～4次(加入乙醚可降低羟胺的溶解度)，将滤液转入磨口的烧瓶密封起来。冷却到-10℃，令羟胺析出结晶，抽滤并用预先冷却好的无水乙醚洗涤。可得产品210g(理论量的635%)，密封保存。(*滴液漏斗外设计加热管子可防止内装试剂固化。)

羟胺文献

Involvement of opsins in mammalian sperm thermotaxis.

Sci. Rep. 5 , 16146, (2015)

A unique characteristic of mammalian sperm thermotaxis is extreme temperature sensitivity, manifested by the capacity of spermatozoa to respond to temperature changes of <0.0006 °C as they swim their ...

Sulfur amino acid metabolism in Zucker diabetic fatty rats.

Biochem. Pharmacol. 96 , 256-66, (2015)

The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocyste...

Phosphoproteomic profiling of tumor tissues identifies HSP27 Ser82 phosphorylation as a robust marker of early ischemia.

Sci. Rep. 5 , 13660, (2015)

Delays between tissue collection and tissue fixation result in ischemia and ischemia-associated changes in protein phosphorylation levels, which can misguide the examination of signaling pathway statu...

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羟胺