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二氢奎尼丁

二氢奎尼丁用途

Hydroquinidine是一种抗心律失常剂。

二氢奎尼丁名称

[ CAS 号 ]:
1435-55-8

[ 中文名 ]:
氢化奎宁定

[ 英文名 ]:
Hydroquinidine

[中文别名 ]:

[英文别名 ]:

EINECS 215-862-5
HYDROQUINIDINE
(9S)-6'-Methoxy-10,11-dihydrocinchonan-9-ol
MFCD00135599
(+)-Dihydroquinidine
(9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-
dihydroquinidine
hydroconchinine

二氢奎尼丁生物活性

[ 描述 ]:

Hydroquinidine是一种抗心律失常剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[相关活性小分子]

二氢奎尼丁物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
498.4±30.0 °C at 760 mmHg

[ 熔点 ]:
169-170 ºC

[ 分子式 ]:
C₂₀H₂₆N₂O₂

[ 分子量 ]:
326.433

[ 闪点 ]:
255.2±24.6 °C

[ 精确质量 ]:
326.199432

[ PSA ]:
45.59000

[ LogP ]:
3.77

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.626

[ 储存条件 ]:
室温

二氢奎尼丁MSDS

详细MSDS(安全技术说明书)

二氢奎尼丁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX3016000

CHEMICAL NAME :: Hydroquinidine

CAS REGISTRY NUMBER :: 1435-55-8

LAST UPDATED :: 199607

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H26-N2-O2

MOLECULAR WEIGHT :: 326.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - headache Cardiac - EKG changes not diagnostic of specified effects

REFERENCE :: CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 18,659,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 84,184,1945

二氢奎尼丁安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
36/37-36

[ 危险品运输编码 ]:
UN 1544

[ WGK德国 ]:
3

[ RTECS号 ]:
MX3016000

[ 包装等级 ]:
III

[ 海关编码 ]:
2933990090

二氢奎尼丁合成路线

详细合成路线

二氢奎尼丁上下游产品

二氢奎尼丁上游产品

二氢奎尼丁下游产品

二氢奎尼丁海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

二氢奎尼丁文献

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Phenylalanine ammonia-lyase (PAL) is an important enzyme that links primary metabolism to secondary metabolism. Its efficiency is often a critical factor that affects the overall flux of a related met...

Macromolecular crowding-assisted fabrication of liquid-crystalline imprinted polymers.

Anal. Bioanal. Chem 407(10) , 2923-31, (2015)

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Infect. Immun. 82(8) , 3492-502, (2014)

(p)ppGpp responds to nutrient limitation through a global change in gene regulation patterns to increase survival. The stringent response has been implicated in the virulence of several pathogenic bac...

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