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磺胺噻唑钠

磺胺噻唑钠用途

Sulfathiazole是短效的磺胺类抗生素。

磺胺噻唑钠名称

[ CAS 号 ]:
144-74-1

[ 中文名 ]:
磺胺噻唑钠

[ 英文名 ]:
Sulfathiazole sodium

[中文别名 ]:

磺胺噻唑鈉

[英文别名 ]:

2-Sulfanilamidothiazole sodium salt
Sodium 2-sulfanilamidothiazole
sulphathiazole sodium
MFCD00072133
Monosodium 2-sulfanilamidothiazole
N1-2-thiazolylsulfanilamide sodium salt
EINECS 205-638-5
UNII:PV16N742VM
Sulfathiazole sodium
Sulfathiazole (sodium)

磺胺噻唑钠生物活性

[ 描述 ]:

Sulfathiazole是短效的磺胺类抗生素。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Perez, S., P. Eichhorn, and D.S. Aga, Evaluating the biodegradability of sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim at different stages of sewage treatment. Environ Toxicol Chem, 2005. 24(6): p. 1361-7.

[2]. Haller, M.Y., et al., Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry. J Chromatogr A, 2002. 952(1-2): p. 111-20.

[3]. Kahle, M. and C. Stamm, Time and pH-dependent sorption of the veterinary antimicrobial sulfathiazole to clay minerals and ferrihydrite. Chemosphere, 2007. 68(7): p. 1224-31.

[相关活性小分子]

磺胺噻唑钠物理化学性质

[ 沸点 ]:
479.5ºC at 760mmHg

[ 熔点 ]:
175ºC (form a); 202ºC (form b)

[ 分子式 ]:
C₉H₈N₃NaO₂S₂

[ 分子量 ]:
277.298

[ 闪点 ]:
243.8ºC

[ 精确质量 ]:
276.995575

[ PSA ]:
112.91000

[ LogP ]:
3.04690

[ 蒸汽压 ]:
2.35E-09mmHg at 25°C

[ 储存条件 ]:
2-8℃

磺胺噻唑钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP2450000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-2-thiazolyl-, monosodium salt

CAS REGISTRY NUMBER :: 144-74-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C9-H9-N3-O2-S2.Na

MOLECULAR WEIGHT :: 278.32

WISWESSER LINE NOTATION :: T5N CSJ BMSWR DZ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 45,15,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,284,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1434 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,138,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 708 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JIDXA3 Journal of the Indiana State Medical Association. (Indiana State Medical Assoc., 3935 N. Meridian, Indianapolis, IN 46208) V.1- 1908- Volume(issue)/page/year: 33,503,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 43,328,1940

磺胺噻唑钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25-S23

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
WP2450000

[ 海关编码 ]:
2935009090

磺胺噻唑钠上下游产品

磺胺噻唑钠上游产品

磺胺噻唑钠下游产品

磺胺噻唑钠海关

[ 海关编码 ]: 2934100090

[ 中文概述 ]:
2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

磺胺噻唑钠文献

Gene expression of ribosomal protein mRNA inChironomus riparius: Effects of endocrine disruptor chemicals and antibiotics

Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 156(2) , 113-20, (2012)

Ribosomal protein genes are essential for cellular development. To examine the effects of ribosomal protein genes under various cellular stress conditions in chironomids, ribosomal protein S3 (RpS3) a...

DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.

Nucleic Acids Res. 39 , D1035-41., (2011)

DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, ...

Mechanisms of resistance to trimethoprim, the sulfonamides, and trimethoprim-sulfamethoxazole.

Rev. Infect. Dis. 4 , 261-269, (1982)

A variety of different mechanisms are known to be responsible for either natural or acquired resistance to trimethoprim, the sulfonamides, or trimethoprim-sulfonamide combinations. Some mechanisms of ...

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