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DL-3-氨基异丁酸

DL-3-氨基异丁酸用途

3-Amino-2-methylpropanoic acid 会诱导白色脂肪发生褐变,并与心血管代谢危险因素成反比。

DL-3-氨基异丁酸名称

[ CAS 号 ]:
144-90-1

[ 中文名 ]:
3-氨基异丁酸

[ 英文名 ]:
3-Aminoisobutanoic acid

[中文别名 ]:

α-甲基-β-丙氨酸

[英文别名 ]:

L-3-amino-isobutyric acid
D-3-Amino-2-methylpropanoic acid
EINECS 205-644-8
Propanoic acid, 3-amino-2-methyl-
D-3-Amino-2-methylpropionic acid
(-)-β-Aminoisobutyric acid
D-2-methyl-b-Alanine
b-Aminoisobutyric acid
(±)-b-Aminoisobutyric acid
2-Methyl-b-alanine

DL-3-氨基异丁酸生物活性

[ 描述 ]:

3-Amino-2-methylpropanoic acid 会诱导白色脂肪发生褐变,并与心血管代谢危险因素成反比。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 心血管疾病

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体内研究]

在3-氨基-2-甲基丙酸(BAIBA)处理结束时,小鼠的体重略微降低。使用MRI分析身体成分表明BAIBA治疗显着降低了小鼠的体脂。与对产热和β-氧化基因表达和体重的影响一致,用代谢笼分析表明在BAIBA处理的小鼠中氧消耗(VO2)和全身能量消耗增加,而活性或食物摄入没有任何显着差异。还通过腹膜内葡萄糖耐量试验(IPGTT)攻击小鼠。发现BAIBA可显着改善小鼠的葡萄糖耐量,这可通过IPGTT曲线下的面积来确定[1]。

[动物实验]

小鼠[1]将6周龄小鼠用3-氨基-2-甲基丙酸（BAIBA：100mg / kg /天）处理或保持未处理（对照小鼠）。每周监测它们的重量[1]。

[参考文献]

[1]. Roberts LD, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 7;19(1):96-108.

[相关活性小分子]

DL-3-氨基异丁酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
223.6±23.0 °C at 760 mmHg

[ 熔点 ]:
246.72°C (estimate)

[ 分子式 ]:
C₄H₉NO₂

[ 分子量 ]:
103.120

[ 闪点 ]:
89.0±22.6 °C

[ 精确质量 ]:
103.063332

[ PSA ]:
63.32000

[ LogP ]:
-0.51

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.462

[ 储存条件 ]:
室温，惰性气体

DL-3-氨基异丁酸MSDS

详细MSDS(安全技术说明书)

DL-3-氨基异丁酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
UA2430000

DL-3-氨基异丁酸合成路线

详细合成路线

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DL-3-氨基异丁酸文献

Automated screening of urine samples for carbohydrates, organic and amino acids after treatment with urease.

J. Chromatogr. A. 562(1-2) , 125-38, (1991)

Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease...

Urinary and plasma organic acids and amino acids in chronic fatigue syndrome.

Clin. Chim. Acta 361(1-2) , 150-8, (2005)

Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds ...

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Anal. Chem. 81(10) , 3919-32, (2009)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ...

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