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牛磺胆酸钠

牛磺胆酸钠用途

牛磺胆酸钠(牛磺胆酸钠；N-胆酰金霉素钠)具有显著的生物活性作用,例如通过上调VEGF-A表达抑制肝动脉结扎诱导的胆道损伤。免疫调节作用[1]。

牛磺胆酸钠名称

[ CAS 号 ]:
145-42-6

[ 中文名 ]:
牛磺胆酸钠

[ 英文名 ]:
Sodium taurocholate

[中文别名 ]:

[英文别名 ]:

Taurine, N-choloyl-, monosodium salt
monosodium N-choloyltaurinate
sodium N-choloyltaurinate
MFCD00013050
Taurocholic Acid Sodium Salt from Bovine Bile
froM Bovine Bile
taurocholatesodiumsalt
taurocholic acid sodium salt
Sodium taurocholate
taurocholatesodium

牛磺胆酸钠生物活性

[ 描述 ]:

牛磺胆酸钠(牛磺胆酸钠；N-胆酰金霉素钠)具有显著的生物活性作用,例如通过上调VEGF-A表达抑制肝动脉结扎诱导的胆道损伤。免疫调节作用[1]。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 蛋白酪氨酸激酶 >> VEGFR

[ 靶点 ]

Microbial Metabolite

Human Endogenous Metabolite

[参考文献]

[1]. Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15(2):217-22.

牛磺胆酸钠物理化学性质

[ 熔点 ]:
230 °C

[ 分子式 ]:
C₂₆H₄₄NNaO₇S

[ 分子量 ]:
537.685

[ 精确质量 ]:
537.273621

[ PSA ]:
155.37000

[ LogP ]:
3.49720

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
23 ° (C=3, H2O)

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
> 250 g/L (20 ºC)

牛磺胆酸钠MSDS

牛磺胆酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WX0400000

CHEMICAL NAME :: Taurine, N-choloyl-, sodium salt

CAS REGISTRY NUMBER :: 145-42-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C26-H44-N-O7-S.Na

MOLECULAR WEIGHT :: 537.76

WISWESSER LINE NOTATION :: L E5 B666TJ A1 DQ E1 FY1&2VM2SWO KQ OQ &-NA- &42/32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,32,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80529 No. of Facilities: 126 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3026 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80529 No. of Facilities: 52 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 741 (estimated) No. of Female Employees: 544 (estimated)

牛磺胆酸钠安全信息

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
WX0400000

牛磺胆酸钠合成路线

牛磺胆酸钠上下游产品

牛磺胆酸钠上游产品

牛磺胆酸钠下游产品

牛磺胆酸钠文献

Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol.

J. Physiol. 593(8) , 2097-109, (2015)

Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensin...

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin.

AAPS J. 16(4) , 875-83, (2014)

The effect of food intake on the release and degradation of peptide drugs from solid lipid particles is unknown and was therefore investigated in vitro using different fed state media in a lipolysis m...

Identification of a novel hypocholesterolemic protein, major royal jelly protein 1, derived from royal jelly.

PLoS ONE 9(8) , e105073, (2014)

Royal jelly (RJ) intake lowers serum cholesterol levels in animals and humans, but the active component in RJ that lowers serum cholesterol level and its molecular mechanism are unclear. In this study...

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