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比马前列素

比马前列素用途

Bimatoprost是前列腺素类似物,可作用于眼内高压和青光眼。

比马前列素名称

[ CAS 号 ]:
155206-00-1

[ 中文名 ]:
比马前列素

[ 英文名 ]:
Bimatoprost

[中文别名 ]:

[英文别名 ]:

BiMatoprost HOUSE STANDARD
BiMapnost
Prostamide
17-Phenyl-tri-norprostaglandin F2α-ethyl amide
MFCD03411999
Lumigan
Bimatoprost

比马前列素生物活性

[ 描述 ]:

Bimatoprost是前列腺素类似物,可作用于眼内高压和青光眼。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

研究领域 >> 其他

[参考文献]

[1]. Park J, et al. Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn J Ophthalmol. 2011 Jan;55(1):22-7.

[2]. Filippopoulos T, et al. Periorbital changes associated with topical bimatoprost. Ophthal Plast Reconstr Surg. 2008 Jul-Aug;24(4):302-7.

[相关活性小分子]

比马前列素物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
629.8±55.0 °C at 760 mmHg

[ 熔点 ]:
66-68°C

[ 分子式 ]:
C₂₅H₃₇NO₄

[ 分子量 ]:
415.566

[ 闪点 ]:
334.7±31.5 °C

[ 精确质量 ]:
415.272247

[ PSA ]:
89.79000

[ LogP ]:
1.98

[ 外观性状 ]:
结晶固体

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.591

[ 储存条件 ]:
−20°C

比马前列素MSDS

详细MSDS(安全技术说明书)

比马前列素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

比马前列素合成路线

详细合成路线

比马前列素上下游产品

比马前列素上游产品

比马前列素下游产品

比马前列素制备

以(3aR,4R,5R,6as)-六氢-4-(3-氧-5-苯基-1E-戊烯基)-5-(p-苯基丁酰氧基)-2H-环戊并[b]呋喃-2-酮为原料。
经还原反应，然后将呋喃环上的羰基还原为羟基，水解后再和戊酸的三苯基膦缩合，得到7-(1R,2R,3R,5S)-3,5-二羟基-2-[(3S)-5-苯基-3-[(四氢-2-H-吡喃-2-基)氧]-1E-戊烯基]环戊基]-5Z-庚烯酸。
水解脱去戊烯基侧链的羟基上的保护基。再和碘甲烷溶于二甲基甲酰胺，Cs2CO3作用下得到甲酯，最后和乙胺水溶液反应，得到产物。

比马前列素文献

A retrospective review and observational study of outcomes and safety of bimatoprost ophthalmic solution 0.03% for treating eyelash hypotrichosis.

Dermatol. Surg. 40(10) , 1118-24, (2014)

The efficacy and safety of bimatoprost ophthalmic solution 0.03% for treating hypotrichosis were shown in a randomized controlled trial and in an open-label study. To date, no data on real-world exper...

Conjunctiva-associated lymphoid tissue (CALT) reactions to antiglaucoma prostaglandins with or without BAK-preservative in rabbit acute toxicity study.

PLoS ONE 7 , e33913, (2012)

Conjunctiva-associated lymphoid tissue (CALT) is closely associated with ocular surface immunity. This study investigated the effects of antiglaucoma prostaglandin analogs with or without benzalkonium...

Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes.

Mol. Vis. 18 , 431-8, (2012)

To determine the proinflammatory cytokine profile of aqueous humor from glaucomatous eyes.Aqueous humor samples were prospectively collected from 38 eyes (26 primary open angle glaucoma [POAG] and 12 ...

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