美噻吨盐酸盐
美噻吨盐酸盐用途
Metixene hydrochloride 是一种抗胆碱能、抗帕金森剂,能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体 (muscarinic receptor) 结合,IC50 和 Kd 值分别为 55 nM 和 15 nM。
美噻吨盐酸盐名称
[ CAS 号 ]:
1553-34-0
[ 中文名 ]:
美噻吨盐酸盐
[ 英文名 ]:
Metixene hydrochloride
[英文别名 ]:
- methypranol
- Trimepranol
- metipranolol
- Turoptin
- Methixenhydrochlorid
- metipronalol
- Metixene hydrochloride
- OptiPranolol
- Disorat
- Metipranololum
美噻吨盐酸盐生物活性
[ 描述 ]:
Metixene hydrochloride 是一种抗胆碱能、抗帕金森剂,能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体 (muscarinic receptor) 结合,IC50 和 Kd 值分别为 55 nM 和 15 nM。
[ 相关类别 ]:
[ 靶点 ]
IC50: 55 nM (mAChR)[1] Ki: 15 nM (mAChR)[1]
[参考文献]
美噻吨盐酸盐物理化学性质
[ 沸点 ]:
419.7ºC at 760 mmHg
[ 分子式 ]:
C20H24ClNS
[ 分子量 ]:
345.93
[ 闪点 ]:
207.6ºC
[ 精确质量 ]:
345.13200
[ PSA ]:
28.54000
[ LogP ]:
5.75490
[ 蒸汽压 ]:
2.99E-07mmHg at 25°C
美噻吨盐酸盐毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TN1944000
- CHEMICAL NAME :
- Piperidine, 1-methyl-3-(thioxanthen-9-ylmethyl)-, hydrochloride
- CAS REGISTRY NUMBER :
- 1553-34-0
- LAST UPDATED :
- 198812
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C20-H23-N-S.Cl-H
- MOLECULAR WEIGHT :
- 345.96
- WISWESSER LINE NOTATION :
- T C666 BS IHJ I1- CT6NTJ A1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1460 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 295 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1519 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 141,331,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 346 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 108 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 238 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,824,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 63,568,1964
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