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(S)-SNAP5114

(S)-SNAP5114用途

(S)-SNAP5114 是一个选择性的 GABA 转运的抑制剂,其对hGAT-3和rGAT-2的 IC50 值分别为5 μM 和21 μM。 (S)-SNAP5114 是一种抗惊厥药。

(S)-SNAP5114名称

[ CAS 号 ]:
157604-55-2

[ 中文名 ]:
(S)-SNAP5114

[ 英文名 ]:
(S)-SNAP 5114

[英文别名 ]:

HMS3268E15
SNAP-5114
Pseudo RACK1
(S)-SNAP-5114

(S)-SNAP5114生物活性

[ 描述 ]:

(S)-SNAP5114 是一个选择性的 GABA 转运的抑制剂,其对hGAT-3和rGAT-2的 IC50 值分别为5 μM 和21 μM。 (S)-SNAP5114 是一种抗惊厥药。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[ 靶点 ]

IC50: 5 μM (hGAT-3), 21 μM (rGAT-2)[1].

[参考文献]

[1]. Borden LA, et al. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors Channels. 1994;2(3):207-13.

[2]. Borden LA, et al. GABA transporter heterogeneity: pharmacology and cellular localization. Neurochem Int. 1996 Oct;29(4):335-56.

(S)-SNAP5114物理化学性质

[ 密度 ]:
1.175g/cm3

[ 沸点 ]:
643.9ºC at 760mmHg

[ 分子式 ]:
C₃₀H₃₅NO₆

[ 分子量 ]:
505.60

[ 闪点 ]:
343.2ºC

[ 精确质量 ]:
505.24600

[ PSA ]:
77.46000

[ LogP ]:
4.75540

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.571

[ 储存条件 ]:
-20°C

(S)-SNAP5114安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

(S)-SNAP5114文献

GABA transporter heterogeneity: pharmacology and cellular localization.

Neurochem. Int. 29 , 335, (1996)

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. GABA is cleared from the synaptic cleft by specific, high-affinity, sodium- and chloride-dependent trans...

GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors.

Neuropharmacology 39 , 2399-2407, (2000)

The present study examines the effect of tiagabine (a selective inhibitor of GABA transporter 1, GAT-1), SNAP-5114 (a semi-selective inhibitor of rat GAT-3/mouse GAT4) and NNC 05-2045 (a non-selective...

GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii.

PLoS Pathog. 8 , e1003051, (2012)

During acute infection in human and animal hosts, the obligate intracellular protozoan Toxoplasma gondii infects a variety of cell types, including leukocytes. Poised to respond to invading pathogens,...

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