左旋千金藤啶碱

左旋千金藤啶碱用途

L-Stepholidine (Stepholidine),一种从中草药 Stephania intermedia 提取的生物碱,是已知的第一种同时具有多巴胺受体 D1 (dopamine D1 receptor) 激动剂和多巴胺受体 D2 (dopamine D2 receptor) 拮抗剂。L-Stepholidine (Stepholidine) 具有神经保护作用,并抑制海洛因诱导的恢复。L-Stepholidine (Stepholidine) 是治疗阿片成瘾的一种潜在药物。

左旋千金藤啶碱名称

[ CAS 号 ]:
16562-13-3

[ 中文名 ]:
左旋千金藤啶碱

[ 英文名 ]:
(S)-(-)-Stepholidine

[英文别名 ]:

(-)-Stepholidine
L-Stepholidine
Stepholidine

左旋千金藤啶碱生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[ 靶点 ]

Dopamine D1 receptor[1] Dopamine D2 receptor[1]

[参考文献]

[1]. Ma B, et al. L-stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement. Neurosci Lett. 2014 Jan 24;559:67-71.

[2]. Zhou M, et al. The Neuroprotective Effect of L-Stepholidine on Methamphetamine-Induced Memory Deficits in Mice. Neurotox Res. 2019 Aug;36(2):376-386.

[3]. Wang W, et al. The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats. Neuropharmacology. 2007 Feb;52(2):355-61. Epub 2006 Oct 5.

左旋千金藤啶碱物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
524.0±50.0 °C at 760 mmHg

[ 熔点 ]:
120-122ºC

[ 分子式 ]:
C₁₉H₂₁NO₄

[ 分子量 ]:
327.374

[ 闪点 ]:
270.7±30.1 °C

[ 精确质量 ]:
327.147064

[ PSA ]:
62.16000

[ LogP ]:
2.16

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.680

左旋千金藤啶碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DR9823500

CHEMICAL NAME :: 13a-alpha-Berbine-2,10-diol, 3,9-dimethoxy-

CAS REGISTRY NUMBER :: 16562-13-3

LAST UPDATED :: 198707

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H21-N-O4

MOLECULAR WEIGHT :: 327.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 928 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 6,156,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 358 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 7,522,1986

左旋千金藤啶碱安全信息

[ 海关编码 ]:
2933990090

左旋千金藤啶碱合成路线

详细合成路线

左旋千金藤啶碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%