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葡萄糖酸氯己定

葡萄糖酸氯己定用途

Chlorhexidine双葡萄糖酸盐是抗菌剂,对革兰氏阴性和阳性菌有效。

葡萄糖酸氯己定名称

[ CAS 号 ]:
18472-51-0

[ 中文名 ]:
葡萄糖酸氯己定

[ 英文名 ]:
Chlorhexidine digluconate

[中文别名 ]:

[英文别名 ]:

Maskin
Unisept
Chlorhexamed
1,6-Bis(N5-[p-chlorophenyl]-N1-biguanido)hexane
Septeal
Betasept
Peridex
Rotersept
hibitane
Manusan

葡萄糖酸氯己定生物活性

[ 描述 ]:

Chlorhexidine双葡萄糖酸盐是抗菌剂,对革兰氏阴性和阳性菌有效。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Jenkins, S., M. Addy, and W. Wade, The mechanism of action of chlorhexidine. A study of plaque growth on enamel inserts in vivo. J Clin Periodontol, 1988. 15(7): p. 415-24.

[2]. Maki, D.G., M. Ringer, and C.J. Alvarado, Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet, 1991. 338(8763): p. 339-43.

[相关活性小分子]

葡萄糖酸氯己定物理化学性质

[ 密度 ]:
1.06 g/mL at 25 °C(lit.)

[ 沸点 ]:
699.3ºC at 760 mmHg

[ 熔点 ]:
134ºC

[ 分子式 ]:
C₃₄H₅₄Cl₂N₁₀O₁₄

[ 分子量 ]:
897.757

[ 闪点 ]:
376.7ºC

[ 精确质量 ]:
896.319824

[ PSA ]:
444.48000

[ 外观性状 ]:
无色至淡黄色透明液体

[ 蒸汽压 ]:
0mmHg at 25°C

[ 储存条件 ]:
库房低温通风干燥

葡萄糖酸氯己定MSDS

详细MSDS(安全技术说明书)

葡萄糖酸氯己定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU1950000

CAS REGISTRY NUMBER :: 18472-51-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C22-H30-Cl2-N10.2C6-H12-O7

MOLECULAR WEIGHT :: 897.88

WISWESSER LINE NOTATION :: GR DMYUM&MYUM&M6MYUM&MYUM&MR DG &QVYQYQYQYQ1Q 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 1 mg/L

REFERENCE :: ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953- Volume(issue)/page/year: 32,171,1986 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3093 No. of Facilities: 4592 (estimated) No. of Industries: 5 No. of Occupations: 36 No. of Employees: 643404 (estimated) No. of Female Employees: 561783 (estimated)

葡萄糖酸氯己定安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
50/53

[ 安全声明 (欧洲) ]:
61

[ 危险品运输编码 ]:
UN 3082 9 / PGIII

[ WGK德国 ]:
-

[ 海关编码 ]:
3004909090

葡萄糖酸氯己定海关

[ 海关编码 ]: 3004909090

葡萄糖酸氯己定文献

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Incorporation of chlorhexidine gluconate or diacetate into a glass-ionomer cement: porosity, surface roughness, and anti-biofilm activity.

Am. J. Dent. 27(6) , 318-22, (2014)

To evaluate the porosity, surface roughness and anti-biofilm activity of a glass-ionomer cement (GIC) after incorporation of different concentrations of chlorhexidine (CHX) gluconate or diacetate.For ...

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