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葡萄糖酸内酯

葡萄糖酸内酯用途

D-(+)-Glucono-1,5-lactone 是一种聚羟基酸,能够螯合金属离子,保湿,具有抗氧化活性。

葡萄糖酸内酯名称

[ CAS 号 ]:
90-80-2

[ 中文名 ]:
D-(+)-葡萄糖酸δ-内酯

[ 英文名 ]:
Delta-Gluconolactone

[中文别名 ]:

[英文别名 ]:

D-Gluconolactone
EINECS 202-016-5
δ-Gluconolactone
D-Gluconic acid-1,5-lactone
D-Glucono-1,5-lactone
D-Glucono-d-lactone
gluconolactone
D-Gluconic acid 1,5-lactone
d-gluconic acid d-lactone
Delta-Gluconolactone

葡萄糖酸内酯生物活性

[ 描述 ]:

D-(+)-Glucono-1,5-lactone 是一种聚羟基酸,能够螯合金属离子,保湿,具有抗氧化活性。

[ 相关类别 ]:

天然产物 >> 糖和糖苷

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

D -(+)-葡糖酸-1,5-内酯是D-葡萄糖酸的内酯(环酯)。 D -(+)-葡萄糖酸-1,5-内酯通常存在于蜂蜜,果汁,个人润滑剂和葡萄酒中。 D -(+)-葡萄糖酸-1,5-内酯是中性的,但在水中水解成酸性的葡萄糖酸,给食物增添了浓郁的味道,尽管它含有大约三分之一的柠檬酸酸味。它被代谢为葡萄糖; 1克D -(+)-葡萄糖酸-1,5-内酯产生与1克糖大致相同的代谢能量。加入水后,GDL部分水解成葡萄糖酸,内酯形式和酸形式之间的平衡被确定为化学平衡。 D -(+)-葡萄糖酸-1,5-内酯的水解速率因热和高pH值而增加[1]。

[参考文献]

[1]. Xu Y, et al. Aggregation and structural changes of silver carp actomyosin as affected by mild acidification with D-gluconic acid δ-lactone. Food Chem. 2012 Sep 15;134(2):1005-10.

[相关活性小分子]

葡萄糖酸内酯物理化学性质

[ 密度 ]:
0.6

[ 沸点 ]:
230.35°C

[ 熔点 ]:
151-155 ºC

[ 分子式 ]:
C₆H₁₀O₆

[ 分子量 ]:
178.140

[ 闪点 ]:
192.3±20.3 °C

[ 精确质量 ]:
178.047745

[ PSA ]:
107.22000

[ LogP ]:
-2.38

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±2.4 mmHg at 25°C

[ 折射率 ]:
1.608

[ 储存条件 ]:
存放于惰性气体之中;避免光,湿气 (分解)

[ 水溶解性 ]:
500 g/L (20 ºC)

葡萄糖酸内酯MSDS

详细MSDS(安全技术说明书)

葡萄糖酸内酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ5184000

CHEMICAL NAME :: Gluconic acid, delta-lactone, D-

CAS REGISTRY NUMBER :: 90-80-2

LAST UPDATED :: 199803

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C6-H10-O6

MOLECULAR WEIGHT :: 178.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 5 mmol/L

REFERENCE :: AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secacus, NJ 07094) V.95- 1974- Volume(issue)/page/year: 109,157,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80419 No. of Facilities: 3748 (estimated) No. of Industries: 25 No. of Occupations: 33 No. of Employees: 20328 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80419 No. of Facilities: 3645 (estimated) No. of Industries: 12 No. of Occupations: 28 No. of Employees: 184229 (estimated) No. of Female Employees: 157249 (estimated)

葡萄糖酸内酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R21

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LZ5184000

[ 海关编码 ]:
2932999099

葡萄糖酸内酯合成路线

详细合成路线

葡萄糖酸内酯上下游产品

葡萄糖酸内酯上游产品

葡萄糖酸内酯下游产品

葡萄糖酸内酯制备

1.原料葡萄糖酸钙先用硫酸进行水解，得葡萄糖酸溶液。经过滤去除硫酸钙沉淀，再用氢氧化钡及草酸精制溶液，并沉降分离，去除溶液中的SO42-及Ca2+。然后通过离子交换树脂，进一步净化葡萄糖酸溶液。将溶液浓缩至80%-85%浓度，加入葡萄糖酸-δ-内酯晶种，继续浓缩并结晶，经离心分离；水洗；干燥得成品。

2.将葡萄糖酸钙先用硫酸进行水解，得葡萄糖酸溶液。经过滤去除硫酸钙沉淀，再用氢氧化钡及草酸精制溶液，并沉降分离，去除溶液中的ＳＯ４２－及Ｃａ２＋。然后通过离子交换树脂，进一步净化葡萄糖酸溶液。将溶液浓缩至８０％～８５％，加入葡萄糖酸δ内酯晶种，继续浓缩并结晶，经离心分离、水洗、干燥即得。

葡萄糖酸内酯海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

葡萄糖酸内酯文献

The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.

Altern. Lab. Anim. 43 , 101-27, (2015)

The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the hum...

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Dehydrodipeptide Hydrogelators Containing Naproxen N-Capped Tryptophan: Self-Assembly, Hydrogel Characterization, and Evaluation as Potential Drug Nanocarriers.

Biomacromolecules 16 , 3562-73, (2015)

In this work, we introduce dipeptides containing tryptophan N-capped with the nonsteroidal anti-inflammatory drug naproxen and C-terminal dehydroamino acids, dehydrophenylalanine (ΔPhe), dehydroaminob...

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