洛沙平

更新时间：2024-01-03 21:58:57

洛沙平用途

Loxapine琥珀酸盐是D2DR/D4DR抑制剂和5-羟色胺受体拮抗剂,有抗精神病活性。

描述	Loxapine琥珀酸盐是D2DR/D4DR抑制剂和5-羟色胺受体拮抗剂,有抗精神病活性。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体研究领域 >> 神经疾病
参考文献	[1]. Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35. [2]. Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30. [3]. Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12(4):277-85. [4]. Kalkman HO, et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):361-4.

描述

Loxapine琥珀酸盐是D2DR/D4DR抑制剂和5-羟色胺受体拮抗剂,有抗精神病活性。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

参考文献

N-甲基哌嗪

109-01-3

2,11-二氯二苯并[b,f]...

3455-14-9

洛沙平

1977-10-2

文献：Schmutz,J. et al. Helvetica Chimica Acta, 1967 , vol. 50, p. 245 - 254

8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine

Loxapina

Dibenzoazepine

Lossapina [DCIT]

Dibenzacepin

2-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,f][1,4]oxazepine

Oxilapine

Cloxazepine

2-chloro-11-(4-methyl-1-piperazinyl)dibenz[b,f][1,4]oxazepine

Loxapinum

Loxitane

Loxapin