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7-甲基鸟苷

7-甲基鸟苷用途

7-Methylguanosine 是一种新型的 cNIIIB nucleotidase 抑制剂,IC50 值为 87.8 ± 7.5 µM。

7-甲基鸟苷名称

[ CAS 号 ]:
20244-86-4

[ 中文名 ]:
7-甲基鸟苷

[ 英文名 ]:
7-METHYLGUANOSINE

[中文别名 ]:

7-甲基鸟嘌呤核苷

[英文别名 ]:

7-methlguanosine
N7-Methylguanosin
7-Methylguanosinium-Kation
7-Methylguanosine
2-amino-6,9-dihydro-7-methyl-6-oxo-9-1H-Purinium
7-methyl-guanosine

7-甲基鸟苷生物活性

[ 描述 ]:

7-Methylguanosine 是一种新型的 cNIIIB nucleotidase 抑制剂,IC50 值为 87.8 ± 7.5 µM。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

研究领域 >> 其他

[参考文献]

[1]. Kozarski M, et al. 7-Methylguanosine monophosphate analogues with 5'-(1,2,3-triazoyl) moiety: Synthesis and evaluation as the inhibitors of cNIIIB nucleotidase. Bioorg Med Chem. 2018 Jan 1;26(1):191-199.

7-甲基鸟苷物理化学性质

[ 熔点 ]:
165ºC

[ 分子式 ]:
C₁₁H₁₆N₅O₅+

[ 分子量 ]:
298.27500

[ 精确质量 ]:
298.11500

[ PSA ]:
150.50000

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 折射率 ]:
1.86

[ 储存条件 ]:
−20°C

7-甲基鸟苷MSDS

7-甲基鸟苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2934999090

7-甲基鸟苷合成路线

7-甲基鸟苷上下游产品

7-甲基鸟苷上游产品

7-甲基鸟苷下游产品

7-甲基鸟苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

7-甲基鸟苷文献

Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting.

J. Chromatogr. A. 1365 , 12-8, (2014)

A series of imprinted polymers targeting nucleoside metabolites, prepared using a template analogue approach, are presented. These were prepared following selection of the optimum functional monomer b...

Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity.

PLoS Genet. 11 , e1005586, (2015)

tRNA is the most highly modified class of RNA species, and modifications are found in tRNAs from all organisms that have been examined. Despite their vastly different chemical structures and their pre...

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.

Proc. Natl. Acad. Sci. U. S. A. 106 , 3484-3489, (2009)

The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to ca...

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