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去甲氧基姜黄素

去甲氧基姜黄素用途

脱甲氧姜黄素(Demethoxycurcumin)是姜黄素的一种主要活性成分,已被证明有抗炎症和对癌细胞毒性作用。

去甲氧基姜黄素名称

[ CAS 号 ]:
22608-11-3

[ 中文名 ]:
脱甲氧姜黄

[ 英文名 ]:
demethoxycurcumin

[英文别名 ]:

Demethoxy Curcumin
demethoxycurcumin

去甲氧基姜黄素生物活性

[ 描述 ]:

脱甲氧姜黄素(Demethoxycurcumin)是姜黄素的一种主要活性成分,已被证明有抗炎症和对癌细胞毒性作用。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

信号通路 >> 自噬 >> 自噬

天然产物 >> 酚类

研究领域 >> 炎症/免疫

[参考文献]

[1]. Somchit M, et al. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15(4):1807-10.

[2]. Wang X, et al. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models. BMC Complement Altern Med. 2014 Mar 5;14:88.

[3]. Ko YC, et al. Demethoxycurcumin Alters Gene Expression Associated with DNA Damage, Cell Cycle and Apoptosis in Human Lung Cancer NCI-H460 Cells In Vitro. In Vivo. 2015 01-02;29(1):83-94.

[4]. Katsidoni V, et al. Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit morphine's rewarding effect in rats. Psychopharmacology (Berl). 2014 Dec;231(23):4467-78.

[相关活性小分子]

去甲氧基姜黄素物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
571.4±50.0 °C at 760 mmHg

[ 熔点 ]:
168ºC

[ 分子式 ]:
C₂₀H₁₈O₅

[ 分子量 ]:
338.354

[ 闪点 ]:
205.5±23.6 °C

[ 精确质量 ]:
338.115417

[ PSA ]:
83.83000

[ LogP ]:
3.15

[ 外观性状 ]:
orange

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.660

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: ≥10mg/mL

去甲氧基姜黄素安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H400

[ 警示性声明 ]:
P273

[ 危害码 (欧洲) ]:
N

[ 风险声明 (欧洲) ]:
50

[ 安全声明 (欧洲) ]:
61

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ 海关编码 ]:
29145090

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去甲氧基姜黄素文献

Therapeutic potential of turmeric in Alzheimer's disease: curcumin or curcuminoids?

Phytother Res. 28(4) , 517-25, (2014)

Alzheimer's disease (AD) is the most common form of dementia. There is limited choice in modern therapeutics, and drugs available have limited success with multiple side effects in addition to high co...

Differential cellular uptake and metabolism of curcuminoids in monocytes/macrophages: regulatory effects on lipid accumulation.

Br. J. Nutr. 112(1) , 8-14, (2014)

We have previously shown that curcumin (CUR) may increase lipid accumulation in cultured human acute monocytic leukaemia cell line THP-1 monocytes/macrophages, but that tetrahydrocurcumin (THC), an in...

Demethoxycurcumin-induced DNA Damage Decreases DNA Repair-associated Protein Expression Levels in NCI-H460 Human Lung Cancer Cells.

Anticancer Res. 35 , 2691-8, (2015)

Demethoxycurcumin (DMC) is a key component of Chinese medicine (Turmeric) and has been proven effective in killing various cancer cells. Its role in inducing cytotoxic effects in many cancer cells has...

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