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6-姜酚

6-姜酚用途

[6]-Gingerol是从生姜中分离的活性物质,具有多种生物活性,包括抗癌,抗炎和抗氧化。

6-姜酚名称

[ CAS 号 ]:
23513-14-6

[ 中文名 ]:
[6]-姜酚

[ 英文名 ]:
6-Gingerol

[中文别名 ]:

[英文别名 ]:

(+)-Gingerol
(S)-[6]Gingerol
(S)-(+)-[6]Gingerol
(+)-[6]-Gingerol
6-Gingerol
(S)-(6)-Gingerol
Gingerol
UNII-925QK2Z900
MFCD00210507
[6]-Gingerol

6-姜酚生物活性

[ 描述 ]:

[6]-Gingerol是从生姜中分离的活性物质,具有多种生物活性,包括抗癌,抗炎和抗氧化。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> AMPK

信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

天然产物 >> 黄酮类化合物

[ 靶点 ]

AMPK

Apoptosis

[体外研究]

[6] -gingerol抑制结肠癌细胞增殖并诱导细胞凋亡,而正常结肠细胞不受影响。 [6] -gingerol下调佛波醇肉豆蔻酸乙酸酯诱导的ERK1/2和JNK MAP激酶的磷酸化和AP-1转录因子的激活,但对p38 MAP激酶的磷酸化和NF-κB活化的作用很小[1] ]。 [6] -甘露醇治疗显示恢复受损的肠屏障功能和抑制DSS处理的Caco-2单层中的促炎反应。 AMPK在[6] -葛根醇治疗[2]时被激活。用[6] -甘露醇处理导致骨肉瘤细胞的生存力以剂量依赖性方式显着降低。同时,在亚G1细胞周期阶段停滞的细胞数量显着增加。 [6] -gingerol诱导caspase级联激活并调节Bcl2和Bax的细胞水平[3]。

[体内研究]

在动物研究中,[6] -gingerol通过恢复体重减轻,减少肠出血和预防结肠长度缩短,显着改善DSS诱导的结肠炎。此外,[6] -金霉醇抑制DSS升高的促炎细胞因子(IL-1β,TNFα和IL-12)的产生[2]。

[细胞实验]

在乙醇中制备[6] - 甘露醇原液（20mg / mL），通过在二甲基亚砜（DMSO）中稀释该原料来制备工作浓度。对于MTT测定，将5×103细胞/孔的人结肠癌细胞和104细胞/孔的小鼠IEC接种在96孔板中。在进行MTT测定之前，用[6] - 甘露醇处理细胞48小时，72小时或96小时，并在膜联蛋白-V染色前处理细胞16小时[1]。

[动物实验]

小鼠：每天给予患有DSS诱导的结肠炎的小鼠不同口服剂量的[6] - 甾醇，持续14天。评估体重和结肠炎症，并测量结肠组织中促炎细胞因子的水平[2]。

[参考文献]

[1]. Radhakrishnan EK, et al. [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS One. 2014 Aug 26;9(8):e104401.

[2]. Chang KW, et al. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food Funct. 2015 Oct;6(10):3334-41.

[3]. Fan J, et al. 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumour Biol. 2015 Feb;36(2):1135-41.

[相关活性小分子]

6-姜酚物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
453.0±35.0 °C at 760 mmHg

[ 熔点 ]:
30 - 32ºC

[ 分子式 ]:
C₁₇H₂₆O₄

[ 分子量 ]:
294.386

[ 闪点 ]:
159.0±19.4 °C

[ 精确质量 ]:
294.183105

[ PSA ]:
66.76000

[ LogP ]:
2.48

[ 外观性状 ]:
淡黄色油性

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.523

[ 储存条件 ]:
?20°C

[ 水溶解性 ]:
可溶于：苯,乙醚,氯仿

6-姜酚MSDS

详细MSDS(安全技术说明书)

6-姜酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HE0757000

CHEMICAL NAME :: 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)-

CAS REGISTRY NUMBER :: 23513-14-6

LAST UPDATED :: 199412

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C17-H26-O4

MOLECULAR WEIGHT :: 294.43

WISWESSER LINE NOTATION :: QY5&1V2R DQ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 200 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 122,87,1983

6-姜酚安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H315-H319-H335

[ 警示性声明 ]:
P261-P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ RTECS号 ]:
HE0757000

[ 海关编码 ]:
2914509090

6-姜酚海关

[ 海关编码 ]: 2914509090

[ 中文概述 ]:
2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

6-姜酚文献

Acute toxicity and genotoxicity study of fermented traditional herb formula Guibi-tang.

J. Ethnopharmacol. 156 , 182-9, (2014)

Guibi-tang (Guipi-tang in Chinese and Kihi-to in Japanese) is a multi-herb traditional medicine commonly prescribed to treat psychoneurosis in East Asia. Although this medicine has been widely used, t...

Integrated LC-MS/MS Analytical Systems and Physical Inspection for the Analysis of a Botanical Herbal Preparation.

Molecules 20 , 10641-56, (2015)

The herbal decoction process is generally inconvenient and unpleasant. To avoid using herbal medicine decoctions, various high-quality industrial and pharmaceutical herbal decoction products have been...

6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression.

Chem. Biol. Interact. 228 , 69-78, (2015)

6-Shogaol, a potent bioactive compound in ginger (Zingiber officinale Roscoe), has been reported for anti-inflammatory and anti-cancer activity. In this study, we investigated the effect of 6-shogaol ...

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