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terameprocol

terameprocol用途

Terameprocol是去甲二氢愈创木酸的合成衍生物,是一种非选择性脂氧合酶抑制剂。Terameprocol具有抗病毒和抗肿瘤作用[1][2][3]。

terameprocol名称

[ CAS 号 ]:
24150-24-1

[ 英文名 ]:
terameprocol

[英文别名 ]:

terameprocol
tetramethyl Nordihydroguaiaretic Acid Exclusive
tetramethyl Nordihydroguaiaretic Acid

terameprocol生物活性

[ 描述 ]:

Terameprocol是去甲二氢愈创木酸的合成衍生物,是一种非选择性脂氧合酶抑制剂。Terameprocol具有抗病毒和抗肿瘤作用[1][2][3]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

[参考文献]

[1]. Hwu JR, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 1. Synthesis, structure identification, and inhibition of tat-regulated HIV transactivation. J Med Chem. 1998 Jul 30;41(16):2994-3000.

[2]. Chen H, et al. Antiviral activities of methylated nordihydroguaiaretic acids. 2. Targeting herpes simplex virus replication by the mutation insensitive transcription inhibitor tetra-O-methyl-NDGA. J Med Chem. 1998 Jul 30;41(16):3001-7.

[3]. Park R, et al. Systemic treatment with tetra-O-methyl nordihydroguaiaretic acid suppresses the growth of human xenograft tumors. Clin Cancer Res. 2005 Jun 15;11(12):4601-9.

terameprocol物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
458.5±40.0 °C at 760 mmHg

[ 分子式 ]:
C₂₂H₃₀O₄

[ 分子量 ]:
358.471

[ 闪点 ]:
108.8±34.2 °C

[ 精确质量 ]:
358.214417

[ PSA ]:
36.92000

[ LogP ]:
5.86

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.522

[ 储存条件 ]:
-20°C，密闭，干燥

terameprocol安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

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terameprocol上游产品

terameprocol下游产品

terameprocol文献

Terameprocol, a novel site-specific transcription inhibitor with anticancer activity.

Drugs 3rd ed., 11 , 204-214, (2008)

Terameprocol, a novel, semisynthetic derivative of a naturally occurring plant lignan, is under development by Erimos Pharmaceuticals LLC for the potential treatment of cancer. The antitumor activity ...

Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01.

PLoS ONE 11 , e0148685, (2016)

The ability of Tetra-O-methyl nordihydroguaiaretic acid (M4N) to induce rapid cell death in combination with Etoposide, Rapamycin, or UCN-01 was examined in LNCaP cells, both in cell culture and anima...

Synthesis of apolipoprotein B lipoparticles to deliver hydrophobic/amphiphilic materials.

ACS Appl. Mater. Interfaces 5 , 7509-16, (2013)

To develop a drug delivery system (DDS), it is critical to address challenging tasks such as the delivery of hydrophobic and amphiphilic compounds, cell uptake, and the metabolic fate of the drug deli...

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