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右泛醇

右泛醇用途

Dexchlorpheniramine马来酸盐是一种抗组胺剂, 具有抗胆碱能特性, 用于治疗过敏性疾病。

右泛醇名称

[ CAS 号 ]:
2438-32-6

[ 中文名 ]:
马来酸右氯苯那敏

[ 英文名 ]:
DexChlorpheniramine Maleate

[中文别名 ]:

[英文别名 ]:

MFCD00079046
Dextrochlorpheniramine maleate
EINECS 219-450-6
d-Chlorpheniramine maleate
S-(+)-Chlorpheniramine maleate salt
Dexchlorpheniramine maleate
Polaramine
Chlorpheniramine d-form maleate
Dexchloropheniramine maleate
Dexchlorpheniramine (maleate)

右泛醇生物活性

[ 描述 ]:

Dexchlorpheniramine马来酸盐是一种抗组胺剂, 具有抗胆碱能特性, 用于治疗过敏性疾病。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体

信号通路 >> 免疫及炎症 >> 组胺受体

研究领域 >> 炎症/免疫

[相关活性小分子]

右泛醇物理化学性质

[ 沸点 ]:
379ºC at 760 mmHg

[ 熔点 ]:
112-115ºC(lit.)

[ 分子式 ]:
C₂₀H₂₃ClN₂O₄

[ 分子量 ]:
390.86100

[ 闪点 ]:
183ºC

[ 精确质量 ]:
390.13500

[ PSA ]:
90.73000

[ LogP ]:
3.53040

[ 外观性状 ]:
白色或近乎于白色,结晶粉末

[ 蒸汽压 ]:
6.04E-06mmHg at 25°C

[ 储存条件 ]:
2-8℃

右泛醇MSDS

详细MSDS(安全技术说明书)

右泛醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US6504000

CAS REGISTRY NUMBER :: 2438-32-6

LAST UPDATED :: 199806

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C16-H19-Cl-N2.C4-H4-O4

MOLECULAR WEIGHT :: 390.90

WISWESSER LINE NOTATION :: T6NJ BYR DG&2N1&1 &QV1U1VQ -+

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 82 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 124,347,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3667 No. of Facilities: 13 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 422 (estimated) No. of Female Employees: 194 (estimated)

右泛醇安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
Missing Phrase - N15.00950417

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
US6504000

[ 海关编码 ]:
2933399090

右泛醇上下游产品

右泛醇上游产品

右泛醇下游产品

右泛醇海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

右泛醇文献

Severe anaphylactic reaction after intracameral antibiotic administration during cataract surgery.

J. Cataract Refract. Surg. 31(3) , 620-1, (2005)

We report a severe anaphylactic reaction that occurred about 5 minutes after 1.0 mg of cefuroxime was injected into the anterior chamber after routine phacoemulsification and intraocular lens implanta...

Aseptic meningitis associated with intravenous administration of dexchlorpheniramine.

Ann. Med. Interne (Paris.) 154(3) , 179-80, (2003)

Drug-induced aseptic meningitis has been reported mainly with the use of nonsteroidal anti-inflammatory drugs, antibiotics, intravenous immunoglobulins and OKT3 antibodies. We describe today a very un...

Determination of chlorpheniramine in human plasma by HPLC-ESI-MS/MS: application to a dexchlorpheniramine comparative bioavailability study.

Biomed. Chromatogr. 24(7) , 774-81, (2010)

In the present study a fast, sensitive and robust validated method to quantify chlorpheniramine in human plasma using brompheniramine as internal standard (IS) is described. The analyte and the IS wer...

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右泛醇