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酚磺乙胺

酚磺乙胺用途

Ethamsylate是一种止血药物, 也抑制和前列腺素的生物合成和作用。

酚磺乙胺名称

[ CAS 号 ]:
2624-44-4

[ 中文名 ]:
酚磺乙胺

[ 英文名 ]:
Etamsylate

[中文别名 ]:

[英文别名 ]:

Diethylamine 2,5-Dihydroxybenzenesulfonate
MFCD00867499
Etamsylate
EINECS 220-090-7
Ethamsylate

酚磺乙胺生物活性

[ 描述 ]:

Ethamsylate是一种止血药物, 也抑制和前列腺素的生物合成和作用。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

研究领域 >> 心血管疾病

[相关活性小分子]

酚磺乙胺物理化学性质

[ 沸点 ]:
496.4ºC at 760 mmHg

[ 熔点 ]:
127-131ºC

[ 分子式 ]:
C₁₀H₁₇NO₅S

[ 分子量 ]:
263.311

[ 闪点 ]:
254ºC

[ 精确质量 ]:
263.082733

[ PSA ]:
115.24000

[ LogP ]:
2.43200

[ 外观性状 ]:
白色晶体或结晶粉末

[ 蒸汽压 ]:
1.13E-10mmHg at 25°C

[ 储存条件 ]:
2~8 ℃

酚磺乙胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DB6145000

CHEMICAL NAME :: Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine

CAS REGISTRY NUMBER :: 2624-44-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C6-H6-O5-S.C4-H11-N

MOLECULAR WEIGHT :: 263.34

WISWESSER LINE NOTATION :: WSQR BQ EQ &2M2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29750 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6040 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Mold - Aspergillus nidulans

DOSE/DURATION :: 1 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974

酚磺乙胺安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2921199090

酚磺乙胺制备

【方法一】
由二乙胺用二氧化硫成盐后与对苯二醌加成而得。将二乙胺、乙醇和水加入反应锅内，冷至0℃，通入二氧化硫至反应液pH=3.5-4为止，反应温度控制在10℃以下，得二乙胺亚硫酸盐溶液。然后，于0-10℃缓缓加入对苯二醌。加毕，减压回收乙醇，冷却结晶，过滤。结晶加蒸馏水加热溶解，用活性炭脱色精制，即得酚磺乙胺成品。

酚磺乙胺海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

酚磺乙胺文献

Application and equivalence assessment for determining ethamsylate by using potassium ferricyanide as spectroscopic probe reagent.

Anal. Sci. 26(11) , 1163-7, (2010)

In this paper, a novel method has been established to determine ethamsylate using potassium ferricyanide as a spectroscopic probe reagent. It has been demonstrated that Fe(III) is reduced to Fe(II) by...

Simultaneous determination of aminomethylbenzoic acid, cefminox sodium and etamsylate in human urine by capillary electrophoresis.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(21) , 1899-903, (2010)

A sensitive and selective capillary electrophoresis method is developed, for the first time, for effective separation and simultaneous determination of aminomethylbezoic acid (PAMBA), cefminox sodium ...

A novel visible spectrophotometric method for the determination of ethamsylate in pharmaceutical preparations and biological samples.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 75(3) , 1013-7, (2010)

A highly sensitive visible spectrophotometric method has been developed to determine ethamsylate in this paper, which is based on using Cu(II) as spectroscopic probe reagent. The study indicates that ...

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