2624-44-4

• 常用中文名：酚磺乙胺
• 常用英文名：Etamsylate
• CAS号：2624-44-4
• 分子式：C₁₀H₁₇NO₅S
• 分子量：263.311
• 相关类别： 原料药 血液系统用药 止血药
• 发布时间：2018-02-05 08:00:00
• 更新时间：2024-01-01 22:19:48
• Ethamsylate是一种止血药物, 也抑制和前列腺素的生物合成和作用。

名称

• 中文名: 酚磺乙胺
• 英文名: 2,5-Dihydroxybenzenesulfonic acid N-ethylethanamine (1:1)
• 中文别名: 二乙胺2,5-二羟基苯磺酸盐; 异戊酰胺.异丙基乙酰胺
• 英文别名: Diethylamine 2,5-Dihydroxybenzenesulfonate; 1-Hydroxy-4-oxo-2,5-cyclohexadiene-1-sulfonic Acid Compd with Diethylamine; 2,5-Dihydroxybenzenesulfonic acid - N-ethylethanamine (1:1); MFCD00867499; Etamsylate; EINECS 220-090-7; Ethamsylate; 2,5-Dihydroxybenzenesulfonic Acid Compd with N-Ethylethanamine; Benzenesulfonic acid, 2,5-dihydroxy-, compd. with N-ethylethanamine (1:1); Benzenesulfonic acid,2,5-dihydroxy-,compd. with N-ethylethanamine

物化性质

• 沸点: 496.4ºC at 760 mmHg
• 熔点: 127-131ºC
• 分子式: C₁₀H₁₇NO₅S
• 分子量: 263.311
• 闪点: 254ºC
• 精确质量: 263.082733
• PSA: 115.24000
• LogP: 2.43200
• 外观性状: 白色晶体或结晶粉末
• 蒸汽压: 1.13E-10mmHg at 25°C
• 储存条件: 2~8 ℃

生物活性

• 描述: Ethamsylate是一种止血药物, 也抑制和前列腺素的生物合成和作用。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
  研究领域 >> 心血管疾病

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DB6145000 CHEMICAL NAME : Benzenesulfonic acid, 2,5-dihydroxy-, compd. with diethylamine CAS REGISTRY NUMBER : 2624-44-4 LAST UPDATED : 199806 DATA ITEMS CITED : 13 MOLECULAR FORMULA : C6-H6-O5-S.C4-H11-N MOLECULAR WEIGHT : 263.34 WISWESSER LINE NOTATION : WSQR BQ EQ &2M2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 29750 mg/kg TOXIC EFFECTS : Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6040 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 760 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 3500 mg/kg TOXIC EFFECTS : Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - excitement MUTATION DATA TYPE OF TEST : Sex chromosome loss and nondisjunction TEST SYSTEM : Mold - Aspergillus nidulans DOSE/DURATION : 1 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,159,1974

安全

• 危害码 (欧洲): Xi
• 海关编码: 2921199090

制备

【方法一】
由二乙胺用二氧化硫成盐后与对苯二醌加成而得。将二乙胺、乙醇和水加入反应锅内，冷至0℃，通入二氧化硫至反应液pH=3.5-4为止，反应温度控制在10℃以下，得二乙胺亚硫酸盐溶液。然后，于0-10℃缓缓加入对苯二醌。加毕，减压回收乙醇，冷却结晶，过滤。结晶加蒸馏水加热溶解，用活性炭脱色精制，即得酚磺乙胺成品。

海关

海关编码	2922299090
中文概述	2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%