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L-谷胱甘肽(氧化型)

L-谷胱甘肽(氧化型)用途

Glutathione oxidized 是通过氧化谷胱甘肽产生的,谷胱甘肽是细胞内一种主要的抗氧化剂和解毒剂。

L-谷胱甘肽(氧化型)名称

[ CAS 号 ]:
27025-41-8

[ 中文名 ]:
L-谷胱甘肽

[ 英文名 ]:
L(-)-Glutathione

[中文别名 ]:

[英文别名 ]:

Glutathione disulfide
Glutathione (oxidized form)
GSSG,Glutathiol
Glutathiol,GSSG
L-Glutathione oxidized
oxigluthione
glutathonedisulfide
glutathione-ssg
Oxiglutatione
GSH disulfide

L-谷胱甘肽(氧化型)生物活性

[ 描述 ]:

Glutathione oxidized 是通过氧化谷胱甘肽产生的,谷胱甘肽是细胞内一种主要的抗氧化剂和解毒剂。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Nur E, et al. Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes. Biochim Biophys Acta. 2011 Nov;1812(11):1412-7.

[相关活性小分子]

L-谷胱甘肽(氧化型)物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
976.3±75.0 °C at 760 mmHg

[ 熔点 ]:
178 °C (dec.)(lit.)

[ 分子式 ]:
C₂₀H₃₂N₆O₁₂S₂

[ 分子量 ]:
612.631

[ 闪点 ]:
544.3±37.1 °C

[ 精确质量 ]:
612.151978

[ PSA ]:
368.24000

[ LogP ]:
1.91

[ 外观性状 ]:
白色冻干的粉末

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.677

[ 储存条件 ]:
2~8°C

[ 水溶解性 ]:
soluble

L-谷胱甘肽(氧化型)MSDS

L-谷胱甘肽(氧化型)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MC0556500

CHEMICAL NAME :: Glycine, L-gamma-glutamyl-L-cysteinyl-, (2,2')-disulfide

CAS REGISTRY NUMBER :: 27025-41-8

LAST UPDATED :: 199212

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C20-H32-N6-O12-S2

MOLECULAR WEIGHT :: 612.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,6793,1989

L-谷胱甘肽(氧化型)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
MC0556500

L-谷胱甘肽(氧化型)合成路线

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L-谷胱甘肽(氧化型)文献

Long-chain fatty acid analogues suppress breast tumorigenesis and progression.

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Obesity and type 2 diabetes (T2D) are associated with increased breast cancer incidence and mortality, whereas carbohydrate-restricted ketogenic diets ameliorate T2D and suppress breast cancer. These ...

Ratios of biliary glutathione disulfide (GSSG) to glutathione (GSH): a potential index to screen drug-induced hepatic oxidative stress in rats and mice.

Anal. Bioanal. Chem 405(8) , 2635-42, (2013)

Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery. Detection of hepatic oxidative stress can be an early indicator of hepatotoxicity and benefits...

Cardiovascular disease-related parameters and oxidative stress in SHROB rats, a model for metabolic syndrome.

PLoS ONE 9(8) , e104637, (2014)

SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this mode...

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