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盐酸替洛隆

盐酸替洛隆用途

Tiloron二盐酸盐是第一个合成的, 小分子量化合物, 是一种口服有效的干扰素诱导剂, 用作抗病毒药物。

盐酸替洛隆名称

[ CAS 号 ]:
27591-69-1

[ 中文名 ]:
替洛隆二盐酸盐

[ 英文名 ]:
Tilorone dihydrochloride

[中文别名 ]:

[英文别名 ]:

2,7-Bis-deae-fluorenone
bis-deae-fluorenonehydrochloride
TILORONE HYDROCHLORIDE
TILORONE 2HCL
MFCD00134071
Tilorone DiHCl
Deae-f
UNII-BJ507J4LKY
Tilorone (dihydrochloride)

盐酸替洛隆生物活性

[ 描述 ]:

Tiloron二盐酸盐是第一个合成的, 小分子量化合物, 是一种口服有效的干扰素诱导剂, 用作抗病毒药物。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶

研究领域 >> 感染

[相关活性小分子]

盐酸替洛隆物理化学性质

[ 密度 ]:
1.102g/cm3

[ 沸点 ]:
552.3ºC at 760 mmHg

[ 熔点 ]:
230-233 °C(lit.)

[ 分子式 ]:
C₂₅H₃₆Cl₂N₂O₃

[ 分子量 ]:
483.471

[ 闪点 ]:
287.8ºC

[ 精确质量 ]:
482.210297

[ PSA ]:
42.01000

[ LogP ]:
5.94320

[ 外观性状 ]:
固体;Light yellow to Brown powder to crystal

[ 蒸汽压 ]:
3.05E-12mmHg at 25°C

[ 储存条件 ]:
室温

盐酸替洛隆MSDS

盐酸替洛隆毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LL9000000

CHEMICAL NAME :: Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)-, dihydrochloride

CAS REGISTRY NUMBER :: 27591-69-1

LAST UPDATED :: 199606

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C25-H34-N2-O3.2Cl-H

MOLECULAR WEIGHT :: 483.53

WISWESSER LINE NOTATION :: L B656 HVJ EO2N2&2 LO2N2&2 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human) Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 852 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 244 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 53500 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 150 mg/kg/5D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 400 mg/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 100 umol/L

REFERENCE :: FEBLAL FEBS Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1968- Volume(issue)/page/year: 28,5,1972 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

盐酸替洛隆安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H315-H319-H335-H351

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38;R40

[ 安全声明 (欧洲) ]:
S7-S22-S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LL9000000

[ 海关编码 ]:
2922509090

盐酸替洛隆合成路线

盐酸替洛隆上下游产品

盐酸替洛隆上游产品

盐酸替洛隆下游产品

盐酸替洛隆海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

盐酸替洛隆文献

Development of sustained-release matrix tablets of BKP-01-041 (tilorone derivative) containing Hypromellose.

Pharmazie 68(10) , 796-9, (2013)

The objective of this research was to develop and evaluate sustained-release matrix tablets of BKP-01-041 (tilorone derivative) based on Hypromellose (hydroxypropyl methylcellulose, HPMC) as the matri...

SAR of α7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.

Bioorg. Med. Chem. Lett. 22 , 1633-8, (2012)

The well-known interferon-inducer tilorone was found to possess potent affinity for the agonist site of the α7 neuronal nicotinic receptor (K(i)=56 nM). SAR investigations determined that both basic s...

Discovery of inhibitors of Bacillus anthracis primase DnaG.

Biochemistry 52(39) , 6905-10, (2013)

Primase DnaG is an essential bacterial enzyme that synthesizes short ribonucleotide primers required for chromosomal DNA replication. Inhibitors of DnaG can serve as leads for development of new antib...

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