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DCP-LA

DCP-LA用途

DCP-LA (FR236924) 是一种亚油酸衍生物，选择性地激活 PKCε。

DCP-LA名称

[ CAS 号 ]:
28399-31-7

[ 中文名 ]:
DCP-LA

[ 英文名 ]:
DCP-LA

[英文别名 ]:

Clobenpropit dihydrobromide
DCP-LA

DCP-LA生物活性

[ 描述 ]:

DCP-LA (FR236924) 是一种亚油酸衍生物,选择性地激活 PKCε。

[ 相关类别 ]:

信号通路 >> 表观遗传学 >> PKC

研究领域 >> 神经疾病

信号通路 >> TGF-beta/Smad 信号通路 >> PKC

[ 靶点 ]

PKCε

[参考文献]

[1]. Kanno T, et al. DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain. Cell Physiol Biochem. 2015;37(1):193-200.

DCP-LA物理化学性质

[ 密度 ]:
0.969g/cm3

[ 沸点 ]:
417.047ºC at 760 mmHg

[ 分子式 ]:
C₂₀H₃₆O₂

[ 分子量 ]:
308.50

[ 闪点 ]:
184.49ºC

[ 精确质量 ]:
308.27200

[ PSA ]:
37.30000

[ LogP ]:
6.04430

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.491

[ 储存条件 ]:
2-8℃

DCP-LAMSDS

详细MSDS(安全技术说明书)

DCP-LA安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

DCP-LA文献

The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site.

J. Lipid Res. 47 , 1146-1156, (2006)

This study examined the effect of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a newly synthesized linoleic acid derivative with cyclopropane rings instead of cis-double bond...

Linoleic acid derivative DCP-LA improves learning impairment in SAMP8.

Neuroreport 17 , 105-108, (2006)

In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency ...

更多文献