<生产厂家价格>

D-异亮氨酸

D-异亮氨酸用途

D-Isoleucine ((R)-Isoleucine) 一种异亮氨酸立体异构体,是 Asc-1 反转运蛋白的选择性激活剂,可通过释放内源性 D-丝氨酸增强海马 CA1-CA3 的长期增效作用。

D-异亮氨酸名称

[ CAS 号 ]:
319-78-8

[ 中文名 ]:
D-异亮氨酸

[ 英文名 ]:
D-Isoleucine

[中文别名 ]:

(2R,3R)-2-氨基-3-甲基戊酸

[英文别名 ]:

(R)-Isoleucine
D-Isoleucine
EINECS 206-269-2
D-(-)-Isoleucine
H-D-Allo-Ile-OH
MFCD00064221
H-D-Ile-OH
(2R,3R)-2-Amino-3-methylpentanoic acid
(2R (3R)-2-Amino-3-methylpentanoic acid

D-异亮氨酸生物活性

[ 描述 ]:

D-Isoleucine ((R)-Isoleucine) 一种异亮氨酸立体异构体,是 Asc-1 反转运蛋白的选择性激活剂,可通过释放内源性 D-丝氨酸增强海马 CA1-CA3 的长期增效作用。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Rosenberg D, et, al. Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity. J Neurosci. 2013 Feb 20;33(8):3533-44.

D-异亮氨酸物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
225.8±23.0 °C at 760 mmHg

[ 熔点 ]:
272-274ºC

[ 分子式 ]:
C₆H₁₃NO₂

[ 分子量 ]:
131.173

[ 闪点 ]:
90.3±22.6 °C

[ 精确质量 ]:
131.094635

[ PSA ]:
63.32000

[ LogP ]:
0.73

[ 外观性状 ]:
白色至淡黄色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.463

[ 储存条件 ]:
室温

D-异亮氨酸MSDS

D-异亮氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NR4700000

CHEMICAL NAME :: Isoleucine, D-

CAS REGISTRY NUMBER :: 319-78-8

BEILSTEIN REFERENCE NO. :: 1721793

LAST UPDATED :: 199803

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H13-N-O2

MOLECULAR WEIGHT :: 131.20

WISWESSER LINE NOTATION :: QVYZY2&1 -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6822 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956

D-异亮氨酸安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R40

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NR4700000

[ 海关编码 ]:
2922499990

D-异亮氨酸合成路线

D-异亮氨酸上下游产品

D-异亮氨酸上游产品

D-异亮氨酸下游产品

D-异亮氨酸制备

以L-别异白氨酸为原料，与乙酸酐进行酰化反应后，产物以酰化酶处理分离L-别异白氨酸后再水解而得。

D-异亮氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

D-异亮氨酸文献

Simultaneous determination of 18 D-amino acids in rat plasma by an ultrahigh-performance liquid chromatography-tandem mass spectrometry method: application to explore the potential relationship between Alzheimer's disease and D-amino acid level alterations.

Anal. Bioanal. Chem 408 , 141-50, (2016)

D-Amino acids are increasingly being recognized as important signaling molecules, and abnormal levels of D-amino acids have been implicated in the pathogenesis of Alzheimer's disease. To evaluate the ...

A Highly Stable D-Amino Acid Oxidase of the Thermophilic Bacterium Rubrobacter xylanophilus.

Appl. Environ. Microbiol. 80(23) , 7219-29, (2015)

d-Amino acid oxidase (DAO) is a biotechnologically attractive enzyme that can be used in a variety of applications, but its utility is limited by its relatively poor stability. A search of a bacterial...

Combination of amino acids reduces pigmentation in B16F0 melanoma cells.

Biol. Pharm. Bull. 30 , 677-681, (2007)

Amino acids, the building blocks of proteins, play significant roles in numerous physiological events in mammals. As the effects of amino acids on melanogenesis have yet to be demonstrated, the presen...

更多文献