<生产厂家价格>

他克林

他克林用途

他克林是一种有效的乙酰胆碱酯酶(AChE)抑制剂(IC50=109 nM),也可作为CYP1A2底物药物。他克林在某些个体中表现出一定的肝毒性。他克林可用于研究阿尔茨海默病[1][2][3]。

他克林名称

[ CAS 号 ]:
321-64-2

[ 中文名 ]:
9-胺-1,2,3,4-四氢盐酸氯酯

[ 英文名 ]:
Tacrine

[中文别名 ]:

他克林

[英文别名 ]:

EINECS 206-291-2
MFCD00046923
9-Acridinamine, 1,2,3,4-tetrahydro-
1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
9-Amino-1,2,3,4-tetrahydroacridine
Tetrahydroaminocrine
Tenakrin
1,2,3,4-tetrahydro-5-aminoacridine
Cognex
4-Amino-2,3-tetramethylenequinoline

他克林生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> 疼痛

[ 靶点 ]

IC50: 109 nM (AChE)[3]

[参考文献]

[1]. Patocka J, et al. Possible role of hydroxylated metabolites of tacrine in drug toxicity and therapy of Alzheimer's disease. Curr Drug Metab. 2008;9(4):332-335.

[2]. Bhatt S, et al. Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using In Silico, In Vitro, and In Vivo Approaches. ACS Omega. 2022;7(23):20321-20331. Published 2022 Jun 2.

[3]. Romero A, et al. Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease. Bioorg Med Chem Lett. 2013;23(7):1916-1922.

他克林物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
353.8±42.0 °C at 760 mmHg

[ 熔点 ]:
283-284ºC

[ 分子式 ]:
C₁₃H₁₄N₂

[ 分子量 ]:
198.264

[ 闪点 ]:
167.8±27.9 °C

[ 精确质量 ]:
198.115692

[ PSA ]:
38.91000

[ LogP ]:
1.78

[ 外观性状 ]:
白色至黄色固体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.682

[ 储存条件 ]:
室温，干燥，避光

他克林MSDS

他克林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR9532100

CHEMICAL NAME :: Acridine, 1,2,3,4-tetrahydro-9-amino-

CAS REGISTRY NUMBER :: 321-64-2

BEILSTEIN REFERENCE NO. :: 0147610

LAST UPDATED :: 199707

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C13-H14-N2

MOLECULAR WEIGHT :: 198.29

WISWESSER LINE NOTATION :: T C666 BNT&&J IZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 294 mg/kg/14W-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Liver - liver function tests impaired Blood - changes in cell count (unspecified)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 84 mg/kg/6W-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Liver - liver function tests impaired

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 176 mg/kg/7W-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Liver - liver function tests impaired

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Behavioral - euphoria Behavioral - antipsychotic

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 620 mg/kg/18W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

REFERENCE :: ACNSAX Activitas Nervosa Superior. (Avicenum, Malostranske nam. 28, Prague 1, Czechoslovakia) V.1- 1959- Volume(issue)/page/year: 26,84,1984

他克林安全信息

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R25

[ 海关编码 ]:
2933990090

他克林合成路线

他克林上下游产品

他克林上游产品

他克林下游产品

他克林制备

【方法一】
苯胺和羟胺及水合三氯乙醛反应后，再硫酸催化环合得靛红，收率 63.4%。靛红、过量的盐酸羟胺、乙酸钠三水合物和水，在60℃剧烈搅拌后室温放置过夜。过滤，乙醇-水重结晶，得靛红-3-肟，收率92%。靛红-3-肟加热至熔融，剧烈分解生成邻氨基苯甲腈，用乙醚溶解收集。蒸出乙醚后减压蒸馏得产品，收率86.8%，沸点112～114℃/0.8kPa，熔点48～50℃。邻氨基苯甲腈溶于环己酮，加入等摩尔的无水二氯化锌，搅拌回流。冷却过滤，固体用乙醚洗数次后，悬于水中。加30%氢氧化钠至强碱性，用二氯甲烷提取。提取液水洗，干燥，浓缩，用甲苯重结晶，得微黄色片状的他克林结晶，收率92.6%，熔点182～184℃。

他克林海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

他克林