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N-(3-氨丙基)环己胺

N-(3-氨丙基)环己胺用途

N-(3-氨基丙基)环己胺是一种环己胺衍生物,是亚精胺合酶的选择性和竞争性抑制剂。N-(3-氨丙基)环己胺可用于神经系统疾病的研究[1]。

N-(3-氨丙基)环己胺名称

[ CAS 号 ]:
3312-60-5

[ 中文名 ]:
N-(3-氨丙基)环己胺

[ 英文名 ]:
N1-Cyclohexylpropane-1,3-diamine

[中文别名 ]:

[英文别名 ]:

N1-Cyclohexylpropane-1,3-diamine
MFCD00003838
N-Cyclohexylpropane-1,3-diamine
EINECS 222-001-7
3-amino-1-cyclohexylaminopropane
N-Cyclohexyl-1,3-diaminopropane
1-(Cyclohexylamino)-3-aminopropane
N-Cyclohexyltrimethylendiamin
3-(Aminopropyl)cyclohexylamine
3-(Cyclohexylamino)-1-propylamine

N-(3-氨丙基)环己胺生物活性

[ 描述 ]:

N-(3-氨基丙基)环己胺是一种环己胺衍生物,是亚精胺合酶的选择性和竞争性抑制剂。N-(3-氨丙基)环己胺可用于神经系统疾病的研究[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. P J Chu, et al.Antagonistic effect of N-(3-Aminopropyl)cyclohexylamine on neurotrophic action of spermine in primary cultured rat hippocampal and cerebellar neurons. Jpn J Pharmacol. 1995 Dec;69(4):311-5.

N-(3-氨丙基)环己胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
238.7±8.0 °C at 760 mmHg

[ 熔点 ]:
−17-−15 °C(lit.)

[ 分子式 ]:
C₉H₂₀N₂

[ 分子量 ]:
156.268

[ 闪点 ]:
112.3±22.0 °C

[ 精确质量 ]:
156.162643

[ PSA ]:
38.05000

[ LogP ]:
1.27

[ 外观性状 ]:
淡黄色透明液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.484

[ 储存条件 ]:
存放于惰性气体之中;避免空气

N-(3-氨丙基)环己胺MSDS

N-(3-氨丙基)环己胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C: Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S27-S28-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 2

[ WGK德国 ]:
1

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2921300090

N-(3-氨丙基)环己胺合成路线

N-(3-氨丙基)环己胺上下游产品

N-(3-氨丙基)环己胺上游产品

N-(3-氨丙基)环己胺下游产品

N-(3-氨丙基)环己胺海关

[ 海关编码 ]: 2921300090

[ 中文概述 ]:
2921300090 其他环（烷，烯，萜烯）单胺或多胺（包括其衍生物及它们的盐）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

N-(3-氨丙基)环己胺文献

Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues.

Biochem. Pharmacol. 45(9) , 1897-903, (1993)

Several inhibitors of aminopropyltransferases, developed recently in this laboratory, were tested for their specificity by measuring their effects on six enzyme activities related to polyamine biosynt...

Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.

J. Biochem. 117(2) , 339-45, (1995)

The effects of a potent spermidine synthase inhibitor, trans-4-methylcyclohexylamine (4MCHA), and a spermine synthase inhibitor, N-(3-aminopropyl)cyclohexylamine (APCHA), on polyamine biosynthesis and...

Inhibition of cell growth by combination of alpha-difluoromethylornithine and an inhibitor of spermine synthase.

J. Biochem. 117(4) , 824-9, (1995)

The inhibitory effect on cell growth of a combination of alpha-difluoromethylornithine (DFMO) and an inhibitor of aminopropyl transferase was examined. N-(3-aminopropyl)cyclohexylamine (APCHA) and tra...

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