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MTIC

MTIC用途

MTIC是替莫唑胺(TMZ)的活性代谢产物。与TMZ相比,MITC在大脑中的生物利用度较低,因为药物通过生物屏障和肿瘤细胞膜的渗透性会影响生物利用度。MITC对生物膜的亲和力较低[1]。

MTIC名称

[ CAS 号 ]:
3413-72-7

[ 中文名 ]:
3-甲基(三氮杂烯基)咪唑-4 甲酰胺

[ 英文名 ]:
MTIC

[英文别名 ]:

5-Monomethyltriazenoimidazole-4-carboxamide
5-(3-Monomethyl-1-triazeno)imidazole-4-carboxamide
5-(3-Methyl-1-triazeno)imidazole-4-carboxamide
5-(3-methyltriazen-1-yl)imidazole-4-carboxamide
Imidazole-4-carboxamide,5-(3-methyl-1-triazeno)

MTIC生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 神经疾病

[参考文献]

[1]. Ramalho MJ, et al. Biophysical interaction of temozolomide and its active metabolite with biomembrane models: The relevance of drug-membrane interaction for Glioblastoma Multiforme therapy. Eur J Pharm Biopharm. 2019;136:156-163.

MTIC物理化学性质

[ 密度 ]:
1.66g/cm3

[ 沸点 ]:
306.7ºC at 760mmHg

[ 分子式 ]:
C₅H₈N₆O

[ 分子量 ]:
168.15700

[ 闪点 ]:
139.3ºC

[ 精确质量 ]:
168.07600

[ PSA ]:
108.52000

[ LogP ]:
0.81790

[ 折射率 ]:
1.741

[ 储存条件 ]:
-20°C

MTIC毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI4000000

CHEMICAL NAME :: Imidazole-4-carboxamide, 5-(3-methyl-1-triazeno)-

CAS REGISTRY NUMBER :: 3413-72-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C5-H8-N6-O

MOLECULAR WEIGHT :: 168.19

WISWESSER LINE NOTATION :: T5M CNJ DVZ ENUNM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 775 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4450 mg/kg/14W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - uterine tumors

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 1 mmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,2827,1976

MTIC安全信息

[ 海关编码 ]:
2934999090

MTIC合成路线

详细合成路线

MTIC上下游产品

MTIC上游产品

MTIC下游产品

MTIC海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%