卡前列素

卡前列素用途

Carboprost (15(S)-15-Methyl Prostaglandin F2α) 是前列腺素 F2α 的代谢稳定的合成类似物。Carboprost 刺激子宫收缩并引起流产。Carboprost 用于子宫收缩乏力引起的产后出血,以及在妊娠中期终止妊娠。

卡前列素名称

[ CAS 号 ]:
35700-23-3

[ 中文名 ]:
卡前列素

[ 英文名 ]:
Carboprost

[中文别名 ]:

[英文别名 ]:

prostin15m
Methyl-pgf2a
(15S)-15-Methylprostaglandin F2α
15s)-13e
15-Methyl-PGF2a
15-ME-PGF2a
methyldinoprost
(15S)-15-Methyl-PGF2a
Carboprost
(15S)-15-Methyl PGF2a

卡前列素生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> 其他 >> 其他

[体内研究]

Carboprost(15(S)-15甲基前列腺素F2α；15M-PGF2α,12.5mg/只猴)的甲酯在24小时内将血清孕酮降低至预处理值的12%,但孕酮在48小时内恢复正常[1]。

[参考文献]

[1]. S J Carlan, et al. Effect of Intramuscular 15-methyl Prostaglandin F2 Alpha After Second-Trimester Delivery. Obstet Gynecol. 1997 Jan;89(1):5-9.

[2]. J W Wilks, et al. Inhibition of the Monkey Corpus Luteum With 15-methyl Prostaglandins. Prostaglandins. 1980 Nov;20(5):793-805.

卡前列素物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
536.6±50.0 °C at 760 mmHg

[ 熔点 ]:
79-82ºC

[ 分子式 ]:
C₂₁H₃₆O₅

[ 分子量 ]:
368.508

[ 闪点 ]:
292.4±26.6 °C

[ 精确质量 ]:
368.256287

[ PSA ]:
97.99000

[ LogP ]:
2.49

[ 外观性状 ]:
白色或近乎于白色粉末

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.565

[ 储存条件 ]:
-20°C Freezer, Under Inert Atmosphere

卡前列素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK8021000

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-, (5Z,9-alpha,11-alpha,13E,15S)-

CAS REGISTRY NUMBER :: 35700-23-3

LAST UPDATED :: 199612

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C21-H36-O5

MOLECULAR WEIGHT :: 368.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 5 ug/kg

SEX/DURATION :: female 14 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth. (London, UK) V.68-81, 1961-74. For publisher information, see BJOGAS. Volume(issue)/page/year: 79,737,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 12 ug/kg

SEX/DURATION :: female 30 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 14,785,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraplacental

DOSE :: 10 ug/kg

SEX/DURATION :: female 13 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth. (London, UK) V.68-81, 1961-74. For publisher information, see BJOGAS. Volume(issue)/page/year: 79,737,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 60 ug/kg

SEX/DURATION :: female 42 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 21,273,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 10 ug/kg

SEX/DURATION :: female 15 week(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: JOGBAS Journal of Obstetrics and Gynaecology of the British Commonwealth. (London, UK) V.68-81, 1961-74. For publisher information, see BJOGAS. Volume(issue)/page/year: 79,737,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 100 ug/kg

SEX/DURATION :: female 10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,540,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravaginal

DOSE :: 500 ug/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - other measures of fertility

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 151,575,1976 *** REVIEWS *** TOXICOLOGY REVIEW AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 113,130,1972

卡前列素安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36:Irritating to the eyes.

[ 安全声明 (欧洲) ]:
S26-S37/39

[ WGK德国 ]:
2

[ RTECS号 ]:
TU0175000

卡前列素

卡前列素用途

卡前列素名称

卡前列素生物活性

卡前列素物理化学性质

卡前列素毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

卡前列素安全信息

卡前列素上下游产品

卡前列素上游产品

卡前列素下游产品

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