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胆酸钠

胆酸钠用途

【用途一】
防止胆石生成。

【用途二】

用于消炎。

胆酸钠名称

[ CAS 号 ]:
361-09-1

[ 中文名 ]:
胆酸钠

[ 英文名 ]:
sodium cholate

[中文别名 ]:

[英文别名 ]:

colalin
cholic acid sodium
cholsaeure
sodium salt of cholic acid
Cholic acid,sodium salt
EINECS 206-643-5
7,12-Triol
Cholic acid
CHOLALIC ACID
SodiumCholate

胆酸钠生物活性

[ 描述 ]:

Cholic acid sodium 是肝脏中产生的主要胆汁酸,通常与甘氨酸或牛磺酸缀合,有助于脂肪吸收和胆固醇排泄。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体外研究]

胆酸竞争性地结合HepG2细胞上的Na + /牛磺胆酸盐共转运多肽(NTCP),并显着抑制胆酸(CA)-纳米脂质体(LPs)-多柔比星(DOX)-HCl的摄取,这表明CA-LPs-DOX-HCl也通过NTCP介导的内吞途径摄取[1]。

[细胞实验]

用抑制剂NaN3（1mg/mL）、染料木黄酮（50μg/mL）、MβCD（10mM）、制霉菌素（50μg/mL）、氯丙嗪（10μg/mL）和胆酸（1mg/mL）预处理HepG2细胞30分钟，除去抑制剂后，与CA-LPs孵育2小时，LPs的细胞摄取在“体外细胞摄取测定”部分[1]中确定。

[参考文献]

[1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28;12:1673-1684.

[2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr;45(4):346-352.

胆酸钠物理化学性质

[ 沸点 ]:
583.9ºC at 760 mmHg

[ 熔点 ]:
198ºC

[ 分子式 ]:
C₂₄H₄₀NaO₅

[ 分子量 ]:
430.553

[ 闪点 ]:
321ºC

[ 精确质量 ]:
430.269531

[ PSA ]:
100.82000

[ LogP ]:
2.11400

[ 外观性状 ]:
白色晶体

[ 折射率 ]:
35 ° (C=0.6, EtOH)

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (分解)

[ 水溶解性 ]:
150 g/L (20 ºC)

胆酸钠MSDS

详细MSDS(安全技术说明书)

胆酸钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FZ9600000

CHEMICAL NAME :: Cholic acid, sodium salt

CAS REGISTRY NUMBER :: 361-09-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C24-H39-O5.Na

MOLECULAR WEIGHT :: 430.62

WISWESSER LINE NOTATION :: L E5 B666TJ A1 DQ E1 FY1&2VO KQ OQ &-NA- &38/28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - ulceration or bleeding from stomach Gastrointestinal - ulceration or bleeding from small intestine

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),29,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 164 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - other changes Gastrointestinal - hypermotility, diarrhea

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (103),29,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 90,18,1952

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed. Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS. Volume(issue)/page/year: 52,779,1926 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1798 No. of Facilities: 82 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 82 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1798 No. of Facilities: 585 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 6463 (estimated) No. of Female Employees: 4599 (estimated)

胆酸钠安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ RTECS号 ]:
FZ9600000

胆酸钠上下游产品

胆酸钠上游产品

胆酸钠下游产品

胆酸钠制备

1.将猪（或羊、牛）胆汁加热浓缩至半，趁热加入1～2倍体积的95%乙醇，回流提取，得提取液。提取液冷却，过滤，滤液浓缩后得浸膏。浸膏中加入稀盐酸，调节pH=3～4，放置过夜，倾出上清液，过滤，沉淀物为胆汁酸粗品。也可以将胆汁中加入氢氧化钠，加热煮沸20～24h，然后调整pH值为2～3，出现黑色膏状物，取出膏状物洗至中性，得粗胆汁酸。

粗胆汁酸加酸水洗1～2次，再加95%乙醇加热溶解，用碱调pH =8～8.5，然后加活性炭脱色，过滤，滤液蒸馏回收乙醇，然后结晶，过滤，干燥，可制得胆汁酸成品。

胆酸钠