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卡马西平 10,11-环氧化物

卡马西平 10,11-环氧化物用途

卡马西平10,11-环氧化物是卡马西平(HY-B0246)的口服活性代谢产物。卡马西平具有抗惊厥作用。卡马西平可用于癫痫发作的研究[1]。

卡马西平 10,11-环氧化物名称

[ CAS 号 ]:
36507-30-9

[ 中文名 ]:
卡马西平 10,11-环氧化物

[ 英文名 ]:
carbamazepine-10,11-epoxide

[中文别名 ]:

立痛定杂质F

[英文别名 ]:

Carbamazepine 10,11-Epoxide
Carbamazepine epoxide
Carbamazepine-10,11-epoxide
Carbamazepine10,11-Epoxide

卡马西平 10,11-环氧化物生物活性

[ 描述 ]:

卡马西平10,11-环氧化物是卡马西平(HY-B0246)的口服活性代谢产物。卡马西平具有抗惊厥作用。卡马西平可用于癫痫发作的研究[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

卡马西平 10,11-环氧化物物理化学性质

[ 密度 ]:
1.377g/cm3

[ 沸点 ]:
390.2ºC at 760mmHg

[ 熔点 ]:
204-206ºC

[ 分子式 ]:
C₁₅H₁₂N₂O₂

[ 分子量 ]:
252.26800

[ 闪点 ]:
189.8ºC

[ 精确质量 ]:
252.09000

[ PSA ]:
58.86000

[ LogP ]:
3.79470

[ 外观性状 ]:
白色至灰白色至浅黄色粉末或颗粒

[ 折射率 ]:
1.686

[ 储存条件 ]:
−20°C

卡马西平 10,11-环氧化物MSDS

卡马西平 10,11-环氧化物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ4430000

CHEMICAL NAME :: 6H-Dibenz(b,f)oxiren(d)azepine-6-carboxamide, 1a,10b-dihydro-

CAS REGISTRY NUMBER :: 36507-30-9

LAST UPDATED :: 199706

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H12-N2-O2

MOLECULAR WEIGHT :: 252.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 37,12,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9600 mg/kg

SEX/DURATION :: female 2 week(s) pre-mating female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 279,1237,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 19200 mg/kg

SEX/DURATION :: female 2 week(s) pre-mating female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 279,1237,1996

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 32 gm/kg

SEX/DURATION :: female 2 week(s) pre-mating female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 279,1237,1996

卡马西平 10,11-环氧化物安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H411

[ 警示性声明 ]:
P273

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
HQ4430000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933990090

卡马西平 10,11-环氧化物合成路线

卡马西平 10,11-环氧化物上下游产品

卡马西平 10,11-环氧化物上游产品

卡马西平 10,11-环氧化物下游产品

卡马西平 10,11-环氧化物海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

卡马西平 10,11-环氧化物文献

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Vilazodone is a serotonin reuptake inhibitor and 5-HT1A partial agonist approved for the treatment of major depressive disorder in adults. Vilazodone seems to be metabolized primarily by the cytochrom...

Evaluation of the potential for pharmacokinetic drug-drug interaction between armodafinil and carbamazepine in healthy adults.

Clin. Ther. 37(2) , 325-37, (2015)

Polypharmacy is common in psychiatry practice and can lead to an increased risk of drug interactions. Armodafinil, a wakefulness-promoting agent, has been studied as adjunctive therapy for the treatme...

Successful treatment of carbamazepine poisoning with hemodialysis: a case report and review of the literature.

Hemodial. Int. 15(3) , 407-11, (2011)

A 48-year-old man was brought to the emergency room after ingesting an unknown amount of carbamazepine. He was unconscious and not responding to the noxious stimuli. He was intubated and was placed on...

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