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DS2

DS2用途

DS2是δ-GABAA受体的选择性正变构调节剂。DS2选择性增强α4β3δ受体介导的GABA反应。DS2不增强α4β3γ2和α1β3γ2受体的活性。DS2可以缓解疼痛,并有可能用于睡眠障碍研究[1]。

DS2名称

[ CAS 号 ]:
374084-31-8

[ 英文名 ]:
DS2

[英文别名 ]:

DS2生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[参考文献]

[1]. K A Wafford, et al. Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus. Neuropharmacology. 2009 Jan;56(1):182-9.

DS2物理化学性质

[ 分子式 ]:
C₁₈H₁₂ClN₃OS

[ 分子量 ]:
353.82500

[ 精确质量 ]:
353.03900

[ PSA ]:
78.13000

[ LogP ]:
5.35250

DS2MSDS

详细MSDS(安全技术说明书)

DS2安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

DS2文献

LEMming: A Linear Error Model to Normalize Parallel Quantitative Real-Time PCR (qPCR) Data as an Alternative to Reference Gene Based Methods.

PLoS ONE 10 , e0135852, (2015)

Gene expression analysis is an essential part of biological and medical investigations. Quantitative real-time PCR (qPCR) is characterized with excellent sensitivity, dynamic range, reproducibility an...

Context-Dependent Modulation of GABAAR-Mediated Tonic Currents.

J. Neurosci. 36 , 607-21, (2016)

Tonic GABA currents mediated by high-affinity extrasynaptic GABAA receptors, are increasingly recognized as important regulators of cell and neuronal network excitability. Dysfunctional GABAA receptor...

Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors.

J. Pharmacol. Exp. Ther. 357 , 188-204, (2016)

Synaptic GABAA receptors are primary mediators of rapid inhibition in the brain and play a key role in the pathophysiology of epilepsy and other neurologic disorders. The δ-subunit GABAA receptors are...

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DS2