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S-(4-硝基苄基)-6-硫肌苷

S-(4-硝基苄基)-6-硫肌苷用途

Nitrobenzylthioinosine 是一种 ENT1 转运蛋白抑制剂,以高亲和力与 ENT1 转运蛋白结合。Nitrobenzylthioinosine 是一种光亲和探针,用于追踪大脑中腺苷的摄取位点,并且可以穿过血脑屏障。

S-(4-硝基苄基)-6-硫肌苷名称

[ CAS 号 ]:
38048-32-7

[ 中文名 ]:
S-(4-硝基苄基)-6-硫肌苷

[ 英文名 ]:
Nitrobenzylthioinosine

[英文别名 ]:

NBMPR
S-(4-Nitrobenzyl)-6-thioinosine
EINECS 253-753-4
MFCD00005745
6-S-[(4-Nitrophenyl)methyl]-6-thioinosine
NBTI
6-[(4-Nitrobenzyl)thio]-9-β-D-ribofuranosylpurine

S-(4-硝基苄基)-6-硫肌苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 腺苷受体

[ 靶点 ]

ENT1 transporter[1]

[参考文献]

[1]. Lauri Alanko, et al. Nitrobenzylthioinosine (NBMPR) binding and nucleoside transporter ENT1 mRNA expression after prolonged wakefulness and recovery sleep in the cortex and basal forebrain of rat. J Sleep Res. 2003 Dec;12(4):299-304.

[2]. C M Anderson, et al. Ability of nitrobenzylthioinosine to cross the blood-brain barrier in rats. Neurosci Lett. 1996 Nov 29;219(3):191-4.

[3]. P J Marangos, et al. [3H]nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Eur J Pharmacol. 1982 Dec 3;85(3-4):359-60.

S-(4-硝基苄基)-6-硫肌苷物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
770.2±70.0 °C at 760 mmHg

[ 熔点 ]:
187-190 °C(lit.)

[ 分子式 ]:
C₁₇H₁₇N₅O₆S

[ 分子量 ]:
419.412

[ 闪点 ]:
419.6±35.7 °C

[ 精确质量 ]:
419.089966

[ PSA ]:
184.64000

[ LogP ]:
1.20

[ 外观性状 ]:
solid | white

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.808

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
0.1 M HCl: slightly soluble

S-(4-硝基苄基)-6-硫肌苷MSDS

S-(4-硝基苄基)-6-硫肌苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO9025000

CHEMICAL NAME :: 9H-Purine, 6-(((4-nitrophenyl)methyl)thio)-9-beta-D-ribofuranosy l-

CAS REGISTRY NUMBER :: 38048-32-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H17-N5-O6-S

MOLECULAR WEIGHT :: 419.45

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 8 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,1616,1983

S-(4-硝基苄基)-6-硫肌苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UO9025000

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