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曲美布汀

曲美布汀用途

Trimebutine是阿片受体激动剂,有抗毒蕈碱活性。

曲美布汀名称

[ CAS 号 ]:
39133-31-8

[ 中文名 ]:
曲美布汀

[ 英文名 ]:
Trimebutine

[中文别名 ]:

曲美布汀碱

[英文别名 ]:

trimebutine free base
TRIMEBUTIN
Trimebutine hydrochloride
TRIMEBUTINE
EINECS 254-309-2
MFCD00133873
trimebutine maleate

曲美布汀生物活性

[ 描述 ]:

Trimebutine是阿片受体激动剂,有抗毒蕈碱活性。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体

信号通路 >> 神经信号通路 >> 阿片受体

研究领域 >> 代谢疾病

[参考文献]

[1]. Kaneto, H., M. Takahashi, and J. Watanabe, The opioid receptor selectivity for trimebutine in isolated tissues experiments and receptor binding studies. J Pharmacobiodyn, 1990. 13(7): p. 448-53.

[2]. Roman, F.J., et al., Pharmacological properties of trimebutine and N-monodesmethyltrimebutine. J Pharmacol Exp Ther, 1999. 289(3): p. 1391-7.

[3]. Hiyama, T., et al., Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract. J Gastroenterol Hepatol, 2009. 24(4): p. 537-46.

[相关活性小分子]

曲美布汀物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
457.9±34.0 °C at 760 mmHg

[ 熔点 ]:
79ºC

[ 分子式 ]:
C₂₂H₂₉NO₅

[ 分子量 ]:
387.469

[ 闪点 ]:
230.8±25.7 °C

[ 精确质量 ]:
387.204559

[ PSA ]:
57.23000

[ LogP ]:
4.34

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.534

[ 储存条件 ]:
2-8°C

曲美布汀MSDS

详细MSDS(安全技术说明书)

曲美布汀安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2922199090

曲美布汀上下游产品

曲美布汀上游产品

曲美布汀下游产品

曲美布汀海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

曲美布汀文献

Safety, tolerability and pharmacokinetics of trimebutine 3-thiocarbamoylbenzenesulfonate (GIC-1001) in a randomized phase I integrated design study: single and multiple ascending doses and effect of food in healthy volunteers.

Clin. Ther. 36(11) , 1650-64, (2014)

Trimebutine 3-thiocarbamoylbenzenesulfonate (GIC-1001) is a new drug intended to be used for the management of visceral pain in patients undergoing sedation-free, full colonoscopy. The objectives of t...

[Prokinetics in childhood].

Arch. Pediatr. 17(6) , 737-8, (2010)

Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome.

Eur. J. Pharmacol. 636(1-3) , 159-65, (2010)

Trimebutine maleate, which modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome. However, its effect on postinfectious irritable bowel syndro...

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