硬脂酸镁

硬脂酸镁用途

硬脂酸镁是一种常用的药物润滑剂。但硬脂酸镁会对颗粒之间的结合产生不利影响。硬脂酸镁可以用作赋形剂,例如润滑剂。药用辅料,或称药用辅料,是指除药物成分外,在制药过程中使用的其他化学物质。药用辅料一般是指药物制剂中的非活性成分,可以提高药物制剂的稳定性、溶解性和加工性。药用辅料也会影响联合给药药物的吸收、分布、代谢和消除(ADME)过程[1][2]。

硬脂酸镁名称

[ CAS 号 ]:
557-04-0

[ 中文名 ]:
硬质碳酸镁

[ 英文名 ]:
Magnesium stearate

[中文别名 ]:

[英文别名 ]:

MAGNESIUM DISTEARATE
Magnesium stearate
synpro 90
MFCD00036391
Stearic acid, magnesium salt
MAGNESIUM STEARATE (E-470B, F.C.C.) ADITIO
EINECS 209-150-3
Octadecanoic acid, magnesium salt
stearic acid magnesium salt
Octadecanoic acid, magnesium salt (2:1)

硬脂酸镁生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Zuurman K, et al. Effect of magnesium stearate on bonding and porosity expansion of tablets produced from materials with different consolidation properties[J]. International journal of pharmaceutics, 1999, 179(1): 107-115.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

硬脂酸镁物理化学性质

[ 密度 ]:
1.028g/cm3

[ 沸点 ]:
359.4ºC at 760mmHg

[ 熔点 ]:
200 °C(lit.)

[ 分子式 ]:
C₃₆H₇₀MgO₄

[ 分子量 ]:
591.24

[ 闪点 ]:
162.4ºC

[ 精确质量 ]:
590.512451

[ PSA ]:
52.60000

[ LogP ]:
12.50830

[ 外观性状 ]:
白色粉末

[ 折射率 ]:
1.45 (25ºC)

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
Insoluble

硬脂酸镁MSDS

硬脂酸镁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WI4390000

CHEMICAL NAME :: Stearic acid, magnesium salt

CAS REGISTRY NUMBER :: 557-04-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C36-H70-O4.Mg

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1092 gm/kg/13W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 17,51,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81884 No. of Facilities: 2092 (estimated) No. of Industries: 19 No. of Occupations: 34 No. of Employees: 31116 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6914 No. of Facilities: 64 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 320 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81884 No. of Facilities: 5057 (estimated) No. of Industries: 57 No. of Occupations: 78 No. of Employees: 184994 (estimated) No. of Female Employees: 101129 (estimated)

硬脂酸镁安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
-

[ RTECS号 ]:
WI4390000

[ 海关编码 ]:
29157030

硬脂酸镁合成路线

硬脂酸镁上下游产品

硬脂酸镁上游产品

硬脂酸镁下游产品

硬脂酸镁制备

1.硬脂酸钠的制备将4.25份氢氧化钠溶于50份水中，升温至85℃备用。将25份硬脂酸投入反应釜，加热水500份，搅拌下溶解，调节温度为85～90℃。将已制备好的氢氧化钠溶液，在搅拌下徐徐加入到硬脂酸水溶液中，保持温度75～80℃，搅拌下反应至终点。产物硬脂酸钠液保温备用。

2.硬脂酸镁的制备将硫酸镁15份溶解于150份水中，升温至55℃，并缓缓加入到已制备的硬脂酸钠溶液中，在搅拌下进行复分解反应，反应生成的硬脂酸镁以固体析出。反应完成后，静置分出清液，然后经水洗、离心脱水、于80～85℃下干燥，即得成品。

3.将46.6g硬脂酸用164mL的1mol/L氢氧化钠溶液中和，得到50g硬脂酸钠在2L水中。将制得的硬脂酸钠溶液加热到80℃，滴加由20g氯化镁溶于100mL水中制得的溶液，不断搅拌后，很快析出白色沉淀。冷却后滤出，用水洗至无氯离子存在，最后用乙醇洗。将10g产品置于放有浓硫酸的真空干燥器中4周，得到产品A［Mg(C18H35O2)2·2H2O］。将剩余的产品溶解在苯中并回流加热20min，将上层的黄色液体层趁热倒出，并蒸发至干，得到的固体物可用苯重结晶，即得到产品B［Mg(C18H35O2)2］。产品A在烘箱中于105℃下烘2h后也转变为无水物产品B。

硬脂酸镁海关

[ 海关编码 ]: 29157030

硬脂酸镁文献

The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations.

Drug Dev. Ind. Pharm. 41(3) , 502-14, (2015)

Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well ...

Antisolvent precipitation of novel xylitol-additive crystals to engineer tablets with improved pharmaceutical performance.

Int. J. Pharm. 477(1-2) , 282-93, (2014)

The purpose of this work was to develop stable xylitol particles with modified physical properties, improved compactibility and enhanced pharmaceutical performance without altering polymorphic form of...

Adrenaline (epinephrine) microcrystal sublingual tablet formulation: enhanced absorption in a preclinical model.

J. Pharm. Pharmacol. 67(1) , 20-5, (2014)

For anaphylaxis treatment in community settings, adrenaline (epinephrine) administration using an auto-injector in the thigh is universally recommended. Despite this, many people at risk of anaphylaxi...

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