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甲氰菊酯

甲氰菊酯用途

Fenpropathrin 是合成的菊酯杀虫剂。Fenpropathrin可诱发帕金森症状。

甲氰菊酯名称

[ CAS 号 ]:
39515-41-8

[ 中文名 ]:
甲氰菊酯

[ 英文名 ]:
fenpropathrin [ANSI]

[中文别名 ]:

分扑菊

[英文别名 ]:

TAME
PLATINO
danimen
Fenpropathrin
Fenpropathrin PESTANAL(R),analytical standard
HERALD
S 3206
XE-938
MFCD00144305
RODY

甲氰菊酯生物活性

[ 描述 ]:

Fenpropathrin 是合成的菊酯杀虫剂。Fenpropathrin可诱发帕金森症状。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Jing Xiong, et al. Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration. Mol Neurobiol. 2016 Mar;53(2):995-1008.

甲氰菊酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
448.2±35.0 °C at 760 mmHg

[ 熔点 ]:
50 - 51ºC

[ 分子式 ]:
C₂₂H₂₃NO₃

[ 分子量 ]:
349.423

[ 闪点 ]:
195.5±16.2 °C

[ 精确质量 ]:
349.167786

[ PSA ]:
59.32000

[ LogP ]:
5.48

[ 外观性状 ]:
淡黄色至棕色液体或固体,取决于纯度和温度

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

甲氰菊酯MSDS

甲氰菊酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ2090000

CHEMICAL NAME :: Cyclopropanecarboxylic acid, 2,2,3,3-tetramethyl-, cyano(3-phenoxyphenyl)methyl ester

CAS REGISTRY NUMBER :: 39515-41-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C22-H23-N-O3

MOLECULAR WEIGHT :: 349.46

WISWESSER LINE NOTATION :: L3TJ A1 A1 B1 B1 CVOYCN&R COR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 870 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - rigidity (including catalepsy) Behavioral - aggression

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 740 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 510 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 1089 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Micronucleus test

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,169,1995

甲氰菊酯安全信息

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H312-H330-H410

[ 警示性声明 ]:
P260-P273-P280-P284-P301 + P310-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+,N

[ 风险声明 (欧洲) ]:
21-25-26-50/53

[ 安全声明 (欧洲) ]:
S28-S36/37-S38-S45-S60-S61

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ RTECS号 ]:
GZ2090000

[ 海关编码 ]:
2926909010

甲氰菊酯合成路线

甲氰菊酯上下游产品

甲氰菊酯上游产品

甲氰菊酯下游产品

甲氰菊酯制备

1. 2，2，3，3-四甲基环丙烷甲酰氯在正庚烷、水及相转移催化剂存在下，与间苯氧基苯甲醛、氰化钠反应，即得甲氰菊酯。原料消耗定额：菊酸110kg/t、醚醛800kg/t。

2. 2,2,3,3-四甲基环丙烷甲酰氯在正庚烷、水及相转移催化剂存在下，与间苯氧基苯甲醛、氰化钠反应，即得甲氰菊酯。

3.甲氰菊酯的合成甲氰菊酯可通过下列途径合成。

甲氰菊酯海关

[ 海关编码 ]: 2926909010

甲氰菊酯文献

The molecular marker of kdr against fenpropathrin in Tetranychus cinnabarinus.

J. Econ. Entomol. 106(6) , 2457-66, (2013)

The carmine spider mite, Tetranychus cinnabarinus (Boisduval), is one of the most important pests in agricultural industry. Pyrethroid insecticide has been used to control insects and mites worldwide....

Spirodela polyrhiza stimulates the growth of its endophytes but differentially increases their fenpropathrin-degradation capabilities.

Chemosphere 125 , 33-40, (2015)

In situ remediation of organic contaminants via physical, chemical, and biological approaches is a practical technique for cleansing contaminated water and soil. In the present study, we showed that t...

Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.

J. Med. Chem. 51 , 6478-94, (2008)

Hormone sensitive lipase (HSL) has been recently implicated in diabetes and obesity, prompting attempts to discover new HSL inhibitors. Toward this end, we explored the pharmacophoric space of HSL inh...

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