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PD146176

PD146176用途

PD146176 (NSC168807) 是 15-脂氧合酶 (15-LO) 抑制剂,抑制兔网织红细胞中 15-LO 的 Ki 值为 197 nM。PD146176 (NS168807) 在减少动脉粥样硬化方面有显著效果。

PD146176名称

[ CAS 号 ]:
4079-26-9

[ 中文名 ]:
PD146176

[ 英文名 ]:
PD 146176

[英文别名 ]:

indole<3,2-c>-1-thiochromen
6,11-Dihydro<benzothiopyrano<6,3-b]indole
6,11-Dihydro-<1>benzothiopyrano-<4,3-b>indol
6,11-Dihydro[1]benzothiopyrano[4,3-b]indole
6,11-Dihydrothiochromeno[4,3-b]indole
6,11-dihydro-5-thia-11-aza-benzo(a)-fluorene
[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-
NAN-190 hydrobromide
6,11-Dihydro-benzo<b>indolo<2,3-d>thiopyran

PD146176生物活性

[ 描述 ]:

PD146176 (NSC168807) 是 15-脂氧合酶 (15-LO) 抑制剂,抑制兔网织红细胞中 15-LO 的 Ki 值为 197 nM。PD146176 (NS168807) 在减少动脉粥样硬化方面有显著效果。

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 自噬 >> 自噬

[ 靶点 ]

Ki: 197 nM (Rabbit reticulocyte 15-LO)[1]

[参考文献]

[1]. Sendobry SM, et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenaseinhibitor lacking significant antioxidant properties. Br J Pharmacol. 1997 Apr;120(7):1199-206.

PD146176物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
485.4±24.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₁₁NS

[ 分子量 ]:
237.32

[ 闪点 ]:
247.4±22.9 °C

[ 精确质量 ]:
237.061218

[ PSA ]:
41.09000

[ LogP ]:
4.38

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.774

[ 储存条件 ]:
-20°C，密闭，干燥

PD146176MSDS

PD146176安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

PD146176合成路线

PD146176上下游产品

PD146176上游产品

PD146176下游产品

PD146176海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

PD146176文献

Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity.

Neoplasia 12 , 254-63, (2010)

The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogene...

An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection.

PLoS ONE 8 , e67828, (2013)

While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotrie...

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