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N-苄基咪唑

N-苄基咪唑用途

1-苄基-1H-咪唑是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

N-苄基咪唑名称

[ CAS 号 ]:
4238-71-5

[ 中文名 ]:
N-苄基咪唑

[ 英文名 ]:
1-benzylimidazole

[中文别名 ]:

1-苄基咪唑

[英文别名 ]:

1-BENZYL IMIDAZOLE
MFCD00005296
Imidazole,1-benzyl
1H-Imidazole, 1-(phenylmethyl)-
1-benzylimidazole
1H-Imidazole, 1- (phenylmethyl)-
BENZYLIMIDAZOLE
1-Benzyl-1H-imidazole
N-benzylimidazole
EINECS 224-200-4

N-苄基咪唑生物活性

[ 描述 ]:

1-苄基-1H-咪唑是一种生物化学试剂,可作为生物材料或有机化合物用于生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

[体外研究]

苯并咪唑是一种选择性血栓素合成酶抑制剂和联合数据处理程序-葡萄糖醛基转移酶刺激剂。血栓素合成酶是一种细胞色素第450页酶。细胞色素第450页蛋白参与催化药物代谢和胆固醇、类固醇和其他脂类合成的许多反应。该酶在一些病理生理过程中起重要作用,包括止血、心血管疾病和中风。该基因表达两种转录变体。1个-苯并咪唑选择性抑制血栓博烷合成酶活性。1个-苯并咪唑降低大鼠脑缺血再灌注损伤后血栓素b2水平,增加血流量。雄性纬星大鼠经胃给予 1个-苯并咪唑 (25、75和100毫克/千克/天) 可引起剂量依赖性肝炎。1个-苯并咪唑降低血浆甘油三酯水平 60-70%1个-苯并咪唑刺激三种不同形式的联合数据处理程序-葡萄糖醛基转移酶。1个-苯并咪唑对 4个-甲基菊酮、1个-萘酚、吗啡和一种单萜类醇诺波尔的活性显著提高。苯并咪唑呈浓度依赖性增加肝细胞密码1a催化活性和 CYP1A信使核糖核酸

[参考文献]

[1]. Pettigrew LC, Grotta JC, Rhoades HM, et al. Effect of thromboxane synthase inhibition on eicosanoid levels and blood flow in ischemic rat brain[J]. Stroke, 1989, 20(5): 627-632

[2]. Magdalou J, Totis M, Boiteux-Antoine AF, et al. Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxy hydrolases and UDP-glucuronosyltransferases in rat liver[J]. Biochemical pharmacology, 1988, 37(17): 3297-330 Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science , 1998, 5(3): 153-17

[3]. Shen RF, Tai H H. Thromboxanes: synthase and receptors[J]. Journal of biomedical science, 1998, 5(3): 153-17

[4]. Navas JM, Chana A, Herradón B, et al. Induction of CYP1A by the N‐imidazole derivative, 1‐benzylimidazole[J]. Environmental toxicity and chemistry, 2003, 22(4): 830-83

N-苄基咪唑物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
310.0±11.0 °C at 760 mmHg

[ 熔点 ]:
68-70 °C(lit.)

[ 分子式 ]:
C₁₀H₁₀N₂

[ 分子量 ]:
158.20

[ 闪点 ]:
141.3±19.3 °C

[ 精确质量 ]:
158.084396

[ PSA ]:
17.82000

[ LogP ]:
1.46

[ 外观性状 ]:
白色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.580

[ 储存条件 ]:
室温

[ 水溶解性 ]:
insoluble

N-苄基咪唑MSDS

详细MSDS(安全技术说明书)

N-苄基咪唑安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2933290090

N-苄基咪唑合成路线

详细合成路线

N-苄基咪唑上下游产品

N-苄基咪唑上游产品

N-苄基咪唑下游产品

N-苄基咪唑海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-苄基咪唑文献

Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins

Bioorg. Med. Chem. 17 , 896-904, (2009)

This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoret...

Toward prediction of alkane/water partition coefficients.

J. Med. Chem. 51 , 3720-30, (2008)

Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the pa...

QSAR-based solubility model for drug-like compounds.

Bioorg. Med. Chem. 18 , 7078-84, (2010)

Solubility plays a very important role in the selection of compounds for drug screening. In this context, a QSAR model was developed for predicting water solubility of drug-like compounds. First, a se...

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