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藏花素(栀子花果实的提取物)

藏花素(栀子花果实的提取物)用途

Crocin 是一种营养保健品,是从 Crocus sativus 柱头中分离出的主要成分,具有抗炎,抗癌,抗抑郁和抗惊厥等巨大的药理作用。

藏花素(栀子花果实的提取物)名称

[ CAS 号 ]:
42553-65-1

[ 中文名 ]:
西红花苷

[ 英文名 ]:
Crocin

[中文别名 ]:

番红花色素

[英文别名 ]:

Crocetin digentiobiose ester
EINECS 255-881-6
MFCD00017495
CROCIN
Digentiobiosyl 8,8'-Diapo-8,8'-carotenedioate
a-Crocin
Crocetin Digentiobiosyl Ester
Crocin 1

藏花素(栀子花果实的提取物)生物活性

[ 描述 ]:

Crocin 是一种营养保健品,是从 Crocus sativus 柱头中分离出的主要成分,具有抗炎,抗癌,抗抑郁和抗惊厥等巨大的药理作用。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[参考文献]

[1]. Zaghloul MS, et al. Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis. Life Sci. 2019 Aug 26:116794.

藏花素(栀子花果实的提取物)物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
1169.0±65.0 °C at 760 mmHg

[ 熔点 ]:
186° (effervescence)

[ 分子式 ]:
C₄₄H₆₄O₂₄

[ 分子量 ]:
976.965

[ 闪点 ]:
337.8±27.8 °C

[ 精确质量 ]:
976.378723

[ PSA ]:
391.20000

[ LogP ]:
-0.83

[ 外观性状 ]:
红色晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.650

[ 储存条件 ]:
2-8°C

藏花素(栀子花果实的提取物)MSDS

藏花素(栀子花果实的提取物)毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HL7380000

CHEMICAL NAME :: 8,8'-Diapo-psi,psi-carotenedioic acid, bis(6-O-beta-D-glucopyranosyl-beta-D- glucopyranosyl) ester

CAS REGISTRY NUMBER :: 42553-65-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C44-H64-O24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 4,69,1954

藏花素(栀子花果实的提取物)安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
HL7380000

[ 海关编码 ]:
32129000

藏花素(栀子花果实的提取物)合成路线

藏花素(栀子花果实的提取物)上下游产品

藏花素(栀子花果实的提取物)上游产品

藏花素(栀子花果实的提取物)下游产品

藏花素(栀子花果实的提取物)制备

栀子黄色素是栀子果中的黄色色素，主要成分为藏花素，还有藏花酸。
1. 乙醇提取法
黄栀子经除杂、晒干、去皮、粉碎(过0.21mm)，用Bo%的乙醇浸没并搅拌48h(或浸提4次，每次12h)；过滤，滤液中加入等量的120^#汽油，搅拌半小时；静置分层，取下层液(乙醇层)过滤；滤液减压蒸馏回收乙醇得含固形物约50%的浸膏产品。
2. 水提取法
将黄栀子果烘干、去皮、粉碎，过0.21mm筛，加入10倍的软水，浸泡3h；过滤，滤渣用等量的清水搅拌洗涤2次，并滤干；合并滤液，静置4h，先过滤上层清液，再过滤沉淀得清液，控制含干物3.0%～5.0%；常压浓缩至含干物40%左右，然后减压(87~96kPa)浓缩，浓缩液中加入一定量的酒精，使果胶等杂质沉淀出来；静置2～3h，过滤得提纯液，提纯液再经无极性多孔聚合树脂吸附，进一步除去杂质得精制液，蒸馏回收乙醇后喷雾干燥得粉末产品，收率8%。

3.将栀子果实粉碎成粉末，或将粉末用水浸制成橙色液体，或将上述各属植物的花干燥后，用乙醚热浸，再用7%的乙醇冷浸，添加95%乙醇放置后析出的油状物质，用乙醇、乙醚热溶液处理而得晶体。

藏花素(栀子花果实的提取物)文献

Gastroprotective effect of crocin in ethanol-induced gastric injury in rats.

Chem. Biol. Interact. 229 , 26-35, (2015)

The present study investigated the gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Rats were allocated into a normal group, an ulcer group, a crocin-treated group, an ulce...

The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo.

J. Ethnopharmacol. 156 , 33-40, (2014)

Gardenia jasminoides Ellis has been used in traditional medicine for treatment of inflammation, edema, and dermaitis. The aim of this study was to investigate the mechanism by which Gardenia jasminoid...

Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets.

J. Thromb. Thrombolysis 38(3) , 321-30, (2014)

Recent studies have reported the platelet proapoptotic propensity of plant-derived molecules such as, resveratrol, thymoquinone, andrographolide and gossypol. Meanwhile, there were also reports of phy...

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