GW627368

GW627368(GW627368X)是前列腺素受体EP4高效选择竞争性抑制剂,还对血栓素受体有亲和力。

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

研究领域 >> 炎症/免疫

[1]. Wilson RJ, et al. GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br J Pharmacol. 2006 Jun;148(3):326-39.

[2]. Parida S, et al. Molecular inhibition of prostaglandin E2 with GW627368X: Therapeutic potential and preclinical safety assessment in mouse sarcoma model. Cancer Biol Ther. 2015 Jun 3;16(6):922-32.

[3]. Mason KL, et al. Intrauterine group A streptococcal infections are exacerbated by prostaglandin E2. J Immunol. 2013 Sep 1;191(5):2457-65.

地诺前列酮 | 列腺素 E1 | E7046 | 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸 | PF-04418948 | 2-(2-甲基-1-(4-(甲基磺酰基)-2-(三氟甲基)苄基)-1H-吡咯并[2,3-b]吡啶-3-基)乙酸 | Grapiprant | TG6-10-1 | Taprenepag | 赛乐西帕中间体 | 雷马曲班 | 6-异丙氧基-9-氧杂蒽酮-2-羧酸 | 拉罗皮兰 | 4-(乙酰氨基)-3-[(4-氯苯基)硫代]-2-甲基-1H-吲哚-1-乙酸 | Evatanepag