<生产厂家价格>

SF 11

SF 11用途

SF 11是一种有效的脑渗透神经肽Y Y2受体拮抗剂(IC50=199nm)。抗抑郁药样活性[1][2]。

SF 11名称

[ CAS 号 ]:
443292-81-7

[ 英文名 ]:
SF 11

[英文别名 ]:

HMS2560N17

SF 11生物活性

[ 描述 ]:

SF 11是一种有效的脑渗透神经肽Y Y2受体拮抗剂(IC50=199nm)。抗抑郁药样活性[1][2]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经肽Y受体

[ 靶点 ]

NPYY2 receptor:199 nM (IC50)

[参考文献]

[1]. Domin H, et al. Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. ACS Chem Neurosci. 2019;10(8):3454-3463.

[2]. Brothers SP, et al. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol Pharmacol. 2010;77(1):46-57.

SF 11物理化学性质

[ 分子式 ]:
C₂₇H₃₀N₂O₂S

[ 分子量 ]:
446.60400

[ 精确质量 ]:
446.20300

[ PSA ]:
76.82000

[ LogP ]:
5.44110

SF 11MSDS

详细MSDS(安全技术说明书)

SF 11安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

SF 11文献

Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening.

Mol. Pharmacol. , (2009)

The role of neuropeptide Y Y2 receptor (Y2R) in human diseases such as obesity, mood disorders, and alcoholism could be better resolved by the use of small-molecule chemical probes that are substantia...

更多文献