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科罗索酸

科罗索酸用途

科罗索酸 (Corosolic acid)是一种天然化合物,据报道具有抗肿瘤活性。

科罗索酸名称

[ CAS 号 ]:
4547-24-4

[ 中文名 ]:
科罗索酸

[ 英文名 ]:
Corosolic acid

[中文别名 ]:

[英文别名 ]:

2-a-hydroxyursolic acid
hydroxyursolic acid
Corosolic acid
Urs-12-en-28-oic acid, 2,3-dihydroxy-, (2α,3β)-
2,3-dihydroxyurs-12-en-28-oic acid
2alpha-hydroxyursolic acid
2α-Hydroxyursolic acid
MFCD03840521
(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid

科罗索酸生物活性

[ 描述 ]:

科罗索酸 (Corosolic acid)是一种天然化合物,据报道具有抗肿瘤活性。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 癌症

天然产物 >> 萜类化合物和糖苷

[参考文献]

[1]. Ahn KS, et al. Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent. Planta Med. 1998 Jun;64(5):468-70.

[2]. LI Biao, et al. Mechanism of antitumor action of corosolic acid. China Journal of Modern Medicine, 2015-08

[3]. Ki Hyun Yoo, et al. Corosolic Acid Exhibits Anti-angiogenic and Anti-lymphangiogenic Effects on In Vitro Endothelial Cells and on an In Vivo CT-26 Colon Carcinoma Animal Model. Phytotherapy Research, 2015, 29 (5): 14–723

[相关活性小分子]

科罗索酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
573.3±50.0 °C at 760 mmHg

[ 分子式 ]:
C₃₀H₄₈O₄

[ 分子量 ]:
472.700

[ 闪点 ]:
314.6±26.6 °C

[ 精确质量 ]:
472.355255

[ PSA ]:
77.76000

[ LogP ]:
7.82

[ 外观性状 ]:
细-棕色黄色粉末

[ 蒸汽压 ]:
0.0±3.6 mmHg at 25°C

[ 折射率 ]:
1.567

[ 储存条件 ]:
2-8°C

科罗索酸MSDS

详细MSDS(安全技术说明书)

科罗索酸安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

科罗索酸合成路线

详细合成路线

科罗索酸上下游产品

科罗索酸上游产品

科罗索酸下游产品

科罗索酸文献

Nanoparticles Containing Curcumin Useful for Suppressing Macrophages In Vivo in Mice.

PLoS ONE 10 , e0137207, (2015)

To explore a novel method using liposomes to suppress macrophages, we screened food constituents through cell culture assays. Curcumin was one of the strongest compounds exhibiting suppressive effects...

Simultaneous determination of five triterpene acids in rat plasma by liquid chromatography-mass spectrometry and its application in pharmacokinetic study after oral administration of Folium Eriobotryae effective fraction.

Biomed. Chromatogr. 29 , 1791-7, (2015)

Folium Eriobotryae effective fraction (FEA), the extract of Folium Eriobotryae, had been used as anti-hyperglycemia and anti-hyperlipemia medicine in China. A previous study indicated that euscaphic a...

Corosolic Acid Inhibits Hepatocellular Carcinoma Cell Migration by Targeting the VEGFR2/Src/FAK Pathway.

PLoS ONE 10 , e0126725, (2015)

Inhibition of VEGFR2 activity has been proposed as an important strategy for the clinical treatment of hepatocellular carcinoma (HCC). In this study, we identified corosolic acid (CA), which exists in...

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