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熊果酸

熊果酸用途

熊果酸(Ursolic acid)是一天然三萜羧酸化合物,具有预防和抗癌活性。

熊果酸作用

熊果酸具有抗癌、抗菌、抗炎、降血清转氨酶、降温和安定等作用；可作为药物、食品的乳化剂；动物试验证明，熊果酸具有抗糖尿病作用，对正常小鼠巨噬细胞的吞噬功能有明显增强作用。

熊果酸名称

[ CAS 号 ]:
77-52-1

[ 中文名 ]:
熊果酸

[ 英文名 ]:
Ursolic Acid

[中文别名 ]:

[英文别名 ]:

Masterin
URSON
Merotaine
Neoage UR
EINECS 201-034-0
PRUNOL
MICROMEROL
Ursolicacid
Ursolic acid
MALOL

熊果酸生物活性

[ 描述 ]:

熊果酸(Ursolic acid)是一天然三萜羧酸化合物,具有预防和抗癌活性。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

天然产物 >> 萜类化合物和糖苷

研究领域 >> 癌症

[参考文献]

[1]. Yie Y, et al. Ursolic acid inhibited growth of hepatocellular carcinoma HepG2 cells through AMPKα-mediated reduction of DNA methyltransferase 1. Mol Cell Biochem. 2014 Dec 30.

[2]. Kim M, et al. The combination of ursolic acid and leucine potentiates the differentiation of C2C12 murine myoblasts through the mTOR signaling pathway. Int J Mol Med. 2015 Mar;35(3):755-62.

[3]. Kim ES, et al. Ursolic acid inhibits the invasive phenotype of SNU-484 human gastric cancer cells. Oncol Lett. 2015 Feb;9(2):897-902.

[4]. Li R, et al. Ursolic Acid Promotes Apoptosis of SGC-7901 Gastric Cancer Cells through ROCK/PTEN Mediated Mitochondrial Translocation of Cofilin-1. Asian Pac J Cancer Prev. 2014;15(22):9593-7.

[5]. Hu Z, et al. Ursolic acid improves survival and attenuates lung injury in septic rats induced by cecal ligation and puncture. J Surg Res. 2014 Oct 22. pii: S0022-4804(14)00967-6.

[相关活性小分子]

熊果酸物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
556.9±50.0 °C at 760 mmHg

[ 熔点 ]:
292 °C (dec.)(lit.)

[ 分子式 ]:
C₃₀H₄₈O₃

[ 分子量 ]:
456.700

[ 闪点 ]:
304.7±26.6 °C

[ 精确质量 ]:
456.360352

[ PSA ]:
57.53000

[ LogP ]:
9.01

[ 外观性状 ]:
绿色粉末

[ 蒸汽压 ]:
0.0±3.4 mmHg at 25°C

[ 折射率 ]:
1.555

[ 储存条件 ]:
2~8°C

[ 水溶解性 ]:
insoluble

熊果酸MSDS

详细MSDS(安全技术说明书)

熊果酸安全信息

[ 危害声明 ]:
H413

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
-

[ RTECS号 ]:
YU9520000

[ 海关编码 ]:
2942000000

熊果酸合成路线

详细合成路线

熊果酸上下游产品

熊果酸上游产品

熊果酸下游产品

熊果酸制备

存在于唇形科植物夏枯草(Prunella vulgaris L.)的全草，冬青科冬青属铁冬青(Ilex rotunda Thunb.)的叶等许多植物中。

熊果酸海关

[ 海关编码 ]: 2942000000

熊果酸文献

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions.

Cell Death Dis. 5 , e1555, (2014)

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and results in the activation of the unfolded protein response (UPR), which aims at restoring ER homeostasis. Howev...

Chemical profile and in vivo hypoglycemic effects of Syzygium jambos, Costus speciosus and Tapeinochilos ananassae plant extracts used as diabetes adjuvants in Puerto Rico.

BMC Complement Altern. Med. 15 , 244, (2015)

The increasing numbers of people who use plant-based remedies as alternative or complementary medicine call for the validation of less known herbal formulations used to treat their ailments. Since Pue...

Analysis of triterpenoids and phytosterols in vegetables by thin-layer chromatography coupled to tandem mass spectrometry.

J. Chromatogr. A. 1381 , 229-38, (2015)

Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mang...

更多文献

熊果酸