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古柯二醇

古柯二醇用途

Erythrodiol 是橄榄油的成分。Erythrodiol 通过选择性抑制 ABCA1 蛋白的降解来促进 (ChE)。Erythrodiol 是用于治疗或预防动脉粥样硬化的良好候选物。

古柯二醇名称

[ CAS 号 ]:
545-48-2

[ 中文名 ]:
高根二醇

[ 英文名 ]:
Erythrodiol

[中文别名 ]:

[英文别名 ]:

Olean-12-ene-3,28-diol, (3β)-
HOMOOLESTRANOL
olean-12-ene-3,28-diol
MFCD00017294
Erythrodiol
(3β)-Olean-12-ene-3,28-diol
EINECS 208-890-4
Olean-12-ene-3β,28-diol
12-OLEANENE-3,28-DIOL
(3β)-Olean-12-ène-3,28-diol

古柯二醇生物活性

[ 描述 ]:

Erythrodiol 是橄榄油的成分。Erythrodiol 通过选择性抑制 ABCA1 蛋白的降解来促进 (ChE)。Erythrodiol 是用于治疗或预防动脉粥样硬化的良好候选物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[体外研究]

红细胞二醇(1-15μM; 24小时)以浓度依赖性方式增强ABCA1蛋白水平,并在10和15μM时达到显着性[1]。Western Blot分析[1]细胞系：THP-1巨噬细胞浓度：1μM,2.5μM,5μM,10μM和15μM培养时间：24小时结果：ABCA1蛋白表达增加。

[参考文献]

[1]. Wang L, et al. Erythrodiol, an Olive Oil Constituent, Increases the Half-Life of ABCA1 and Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Front Pharmacol. 2017 Jun 13;8:375.

古柯二醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
520.5±50.0 °C at 760 mmHg

[ 熔点 ]:
230-231ºC(lit.)

[ 分子式 ]:
C₃₀H₅₀O₂

[ 分子量 ]:
442.717

[ 闪点 ]:
209.9±24.7 °C

[ 精确质量 ]:
442.381073

[ PSA ]:
40.46000

[ LogP ]:
9.18

[ 外观性状 ]:
粉末

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.551

[ 储存条件 ]:
2-8℃，干燥，密闭

古柯二醇MSDS

古柯二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
2-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

古柯二醇合成路线

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古柯二醇文献

Potential vasorelaxant effects of oleanolic acid and erythrodiol, two triterpenoids contained in 'orujo' olive oil, on rat aorta.

Br. J. Nutr. 92(4) , 635-42, (2004)

'Orujo' olive oil is obtained by chemical processes from the waste resulting from the mechanical extraction of virgin olive oil. The aim of the present study was to evaluate a new pharmacological prop...

Changes of the wax contents in mixtures of olive oils as determined by gas chromatography with a flame ionization detector.

J. AOAC Int. 95(6) , 1720-4, (2012)

Mixing of refined olive-pomace oil with virgin olive oil is a fraud that has been tried often. Normally, the tests that detected the fraud were determinations of wax esters, erythrodiol+uvaol, and sti...

Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells.

Cytokine 36(5-6) , 211-7, (2006)

Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption. Maslinic acid, oleanolic acid, erythrodiol, and uvaol are pentacycl...

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